4-[[4-[[5-[[2-[[5-[(4,6-Disulfonaphthalen-1-yl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylindol-5-yl]carbamoylamino]-1-methylindol-2-yl]amino]-1-methylpyrrole-2-carbonyl]amino]naphthalene-1,7-disulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[[4-[[5-[[2-[[5-[(4,6-Disulfonaphthalen-1-yl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylindol-5-yl]carbamoylamino]-1-methylindol-2-yl]amino]-1-methylpyrrole-2-carbonyl]amino]naphthalene-1,7-disulfonic acid
• 英文别名: 4-[[4-[[5-[[2-[[5-[(4,6-disulfonaphthalen-1-yl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylindol-5-yl]carbamoylamino]-1-methylindol-2-yl]amino]-1-methylpyrrole-2-carbonyl]amino]naphthalene-1,7-disulfonic acid
• 化学式: C₅₂H₄₄N₁₀O₁₆S₄
• 分子量: 1193.2
• InChiKey: SLQWSBSSWWDJDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  82
• 可旋转键数：
  14
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  411
• 氢给体数：
  10
• 氢受体数：
  17

文献信息

• [EN] NOVEL UREIDO DERIVATIVES OF NAPHTHALENESULFONIC ACIDS<br/>[FR] NOUVEAUX DÉRIVÉS URÉIDO D'ACIDES NAPHTALÈNE-SULFONIQUES
  申请人：NEED PHARMACEUTICALS S R L

  公开号：WO2015008138A1

  公开（公告）日：2015-01-22

  Objects of the present invention are novel ureido derivatives of naphthalensulfonic acids, pharmaceutical compositions comprising such derivatives, a process for the preparation thereof and the use of said derivatives as medications, in particular in the treatment of HIV infections. Formula (I):

  本发明的目标是萘磺酸尿素衍生物的新型化合物、包含这些衍生物的制药组合物、制备这些衍生物的过程以及将这些衍生物用作药物，特别是用于治疗HIV感染的用途。公式（I）：
• NOVEL UREIDO DERIVATIVES OF NAPHTHALENESULFONIC ACIDS
  申请人：NeED PHARMACEUTICALS S.r.l.

  公开号：US20160159778A1

  公开（公告）日：2016-06-09

  Objects of the present invention are novel ureido derivatives of naphthalensulfonic acids, pharmaceutical compositions comprising such derivatives, a process for the preparation thereof and the use of said derivatives as medications, in particular in the treatment of HIV infections. Formula (I):

  本发明的对象是萘磺酸的新型尿素衍生物，包括这种衍生物的药物组合物，其制备过程以及将这些衍生物用作药物，特别是用于治疗HIV感染。 公式（I）：