4-bromo-N-[4-hydroxy-3-(6-hydroxynaphthalen-2-yl)naphthalen-1-yl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-bromo-N-[4-hydroxy-3-(6-hydroxynaphthalen-2-yl)naphthalen-1-yl]benzenesulfonamide
• 化学式: C₂₆H₁₈BrNO₄S
• 分子量: 520.4
• InChiKey: WOFFXYKAJDYLNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• IMMUNOMODULATORY CONJUGATES
  申请人：ASCEND BIOPHARMACEUTICALS LTD

  公开号：US20150030626A1

  公开（公告）日：2015-01-29

  The present invention provides an immunomodulatory compound comprising a carbohydrate polymer comprising mannose, wherein the carbohydrate polymer is conjugated to at least one immune modulator. The present invention also provides for the use of this compound in immunomodulatory compositions for vaccination and gene therapy methods, together with processes for its preparation.

  本发明提供了一种免疫调节化合物，包括一个含有甘露糖的碳水化合物聚合物，其中该碳水化合物聚合物与至少一种免疫调节剂结合。本发明还提供了该化合物在免疫调节组合物中用于疫苗和基因治疗方法的用途，以及其制备方法。
• Methods and compositions for treatment of fibrosis
  申请人：Baylor College of Medicine

  公开号：US10112933B2

  公开（公告）日：2018-10-30

  Embodiments of the invention include methods of treating, preventing, and/or reducing the risk of fibrosis in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction of the risk of fibrosis. In at least particular cases, the small molecules are inhibitors of STAT3.

  本发明的实施方案包括治疗、预防和/或降低有需要的个体纤维化风险的方法。在某些实施方案中，采用特定的小分子来治疗、预防和/或降低纤维化的风险。至少在特定情况下，小分子是 STAT3 的抑制剂。
• Immunomodulatory conjugates
  申请人：ASCEND BIOPHARMACEUTICALS LTD

  公开号：US10344261B2

  公开（公告）日：2019-07-09

  The present invention provides an immunomodulatory compound comprising a carbohydrate polymer comprising mannose, wherein the carbohydrate polymer is conjugated to at least one immune modulator. The present invention also provides for the use of this compound in immunomodulatory compositions for vaccination and gene therapy methods, together with processes for its preparation.

  本发明提供了一种由包含甘露糖的碳水化合物聚合物组成的免疫调节化合物，其中该碳水化合物聚合物与至少一种免疫调节剂共轭。本发明还提供了这种化合物在免疫调节组合物中的用途，用于疫苗接种和基因治疗方法，以及其制备工艺。
• Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia
  申请人：Baylor College of Medicine

  公开号：US10676455B2

  公开（公告）日：2020-06-09

  Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.

  本发明的实施方案包括治疗、预防和/或降低有需要的个体发生选自肌肉萎缩、肌无力、恶病质及其组合的疾病的风险或严重程度的方法。在某些实施方案中，采用特定的小分子来治疗、预防和/或降低肌肉萎缩的风险。至少在特定情况下，小分子是 STAT3 的抑制剂。
• EP3021839B1
  申请人：——

  公开号：EP3021839B1

  公开（公告）日：2021-06-23