1-naphthalen-1-ylsulfonyl-N-pyrrolidin-3-ylpyrrolo[3,2-c]quinolin-4-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-naphthalen-1-ylsulfonyl-N-pyrrolidin-3-ylpyrrolo[3,2-c]quinolin-4-amine
• 化学式: C₂₅H₂₂N₄O₂S
• 分子量: 442.5
• InChiKey: ZEHBPXYRLAHEMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  84.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PYRROLOQUINOLINE DERIVATIVES AS 5-HT6 ANTAGONISTS, PREPARATION METHOD AND USE THEREOF
  申请人：UNIWERSYTET JAGIELLONSKI

  公开号：EP3027613B1

  公开（公告）日：2018-03-28
• Pyrroloquinoline Derivatives as 5-HT6 Antagonists, Preparation Method and Use Thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20160159790A1

  公开（公告）日：2016-06-09

  This invention concerns pyrroloquinoline derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in schizophrenia, anxiety, depression, maniac depression, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, panic attacks, attention deficit hyperactivity disorder, attention deficit disorder, Parkinson's disease, Huntington's disease, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, obesity and type-2 diabetes, functional bowel disorder, Irritable Bowel Syndrome. The compounds have the general formula (XIV), wherein the symbols have the meanings given in the description.
• US9676772B2
  申请人：——

  公开号：US9676772B2

  公开（公告）日：2017-06-13