4-Iodo-5-methyl-1H-indazole | 1956309-36-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 4-Iodo-5-methyl-1H-indazole
• 英文别名: 4-iodo-5-methyl-1H-indazole
• CAS: 1956309-36-6
• 化学式: C₈H₇IN₂
• 分子量: 258.06
• InChiKey: CSNIQSCZDRBPMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] COMBINATION OF AN ERK INHIBITOR AND A KRAS INHIBITOR AND USES THEREOF<br/>[FR] COMBINAISON D'UN INHIBITEUR D'ERK ET D'UN INHIBITEUR DE KRAS ET SES UTILISATIONS
  申请人：SHANGHAI ANTENGENE CORPORATION LTD

  公开号：WO2022262797A1

  公开（公告）日：2022-12-22

  The present disclosure generally relates to the combination of an ERK inhibitor and a KRAS inhibitor, and use thereof.

  本公开涉及ERK抑制剂和KRAS抑制剂的组合及其使用。
• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：GENENTECH INC

  公开号：WO2017205536A2

  公开（公告）日：2017-11-30

  The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.