申请人:Bakker Eric
公开号:US20050023153A1
公开(公告)日:2005-02-03
The present invention is directed to a reversible electrochemical sensor for polyions. The sensor uses active extraction and ion stripping, which are controlled electrochemically. Spontaneous polyion extraction is suppressed by using membranes containing highly lipophilic electrolytes that possess no ion-exchange properties. Reversible extraction of polyions is induced by constant current pulse of fixed duration applied across the membrane. Subsequently, polyions are removed by applying a constant stripping potential. The sensors provide excellent stability and reversibility and allow for measurements of heparin concentration in whole blood samples via protamine titration.
本发明涉及一种多离子可逆电化学传感器。该传感器采用主动萃取和离子剥离技术,通过电化学方法进行控制。通过使用含有不具有离子交换特性的高亲脂性电解质的膜来抑制自发的多离子萃取。通过在膜上施加持续时间固定的恒定电流脉冲,可诱导多离子的可逆萃取。随后,通过施加恒定的剥离电位去除多离子。这种传感器具有出色的稳定性和可逆性,可通过原胺滴定法测量全血样本中的肝素浓度。