5-[4-(6-hydroxy-2-methylchroman-2-ylmethoxy)-benzyl]thiazolidine-2,4-dione | 137786-86-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-[4-(6-hydroxy-2-methylchroman-2-ylmethoxy)-benzyl]thiazolidine-2,4-dione
• 英文别名: 2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2-methyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-；5-[[4-[(6-hydroxy-2-methyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• CAS: 137786-86-8
• 化学式: C₂₁H₂₁NO₅S
• 分子量: 399.467
• InChiKey: AMSJXOCWSLHWJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Thiazolidine derivatives, their preparation and compositions containing them
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0139421B1

  公开（公告）日：1988-04-27
• PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US20190152967A1

  公开（公告）日：2019-05-23

  The invention provides a solution to the clinical problem of retinal pigment epithelium (RPE) degeneration or geographic atrophy (GA) associated with AMD. PPARΥ selective agonists, e.g., troglitazone and analogs thereof are used to reduce or inhibit RPE degeneration, GA, and/or the progression of dry AMD.
• COMPOUNDS AND COMPOSITIONS FOR INHIBITING RETINAL PIGMENT EPITHELIUM DEGENERATION AND METHODS USING THE SAME
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US20200316032A1

  公开（公告）日：2020-10-08

  There are provided inter alia compounds capable of inhibiting retinal pigment epithelium (RPE) degeneration or geography atrophy (GA) associated with age-related macular degeneration (AMD), and methods of using the same.
• US4572912A
  申请人：——

  公开号：US4572912A

  公开（公告）日：1986-02-25
• [EN] PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY<br/>[FR] AGONISTES SÉLECTIFS DES RÉCEPTEURS GAMMA ACTIVÉS PAR LES PROLIFÉRATEURS DE PEROXYSOMES POUR INHIBER LA DÉGÉNÉRESCENCE DE L'ÉPITHÉLIUM PIGMENTAIRE RÉTINIEN OU L'ATROPHIE GÉOGRAPHIQUE
  申请人：THE SCHEPENS EYE RES INST INC

  公开号：WO2017176770A1

  公开（公告）日：2017-10-12

  The invention provides a solution to the clinical problem of retinal pigment epithelium (RPE) degeneration or geographic atrophy (GA) associated with AMD. PPARϒ selective agonists, e.g., troglitazone and analogs thereof are used to reduce or inhibit RPE degeneration, GA, and/or the progression of dry AMD.