4-anilino-6-chloro-2-(N-methylpiperazino)-5-(methylthio)pyrimidine | 83199-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-anilino-6-chloro-2-(N-methylpiperazino)-5-(methylthio)pyrimidine
• 英文别名: 6-chloro-2-(4-methylpiperazin-1-yl)-5-methylsulfanyl-N-phenylpyrimidin-4-amine
• CAS: 83199-77-3
• 化学式: C₁₆H₂₀ClN₅S
• 分子量: 349.887
• InChiKey: IJVGTCBDNXHFEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,4-二甲基哌嗪 以 甲醇 、 甲苯 为溶剂， 反应 5.0h， 生成 4-anilino-6-chloro-2-(N-methylpiperazino)-5-(methylthio)pyrimidine
  参考文献：
  名称：

  4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for .alpha.2-adrenoceptors

  摘要：

  A series of 4-amino-6-chloro-2-piperazinopyrimidines were synthesized and evaluated for their ability to interact with alpha 1- and alpha 2-adrenoceptors in vitro in binding assays using [3H]WB-4101, [3H]clonidine, and [3H]idazoxan as radioligands. Some compounds were also tested as inhibitors of [3H]spiroperidol binding. Several members of this series showed high and selective affinity for alpha 2-adrenoceptors. The nature of the 4-amino substituent seems to be the most critical factor in determining the potency at these receptors.

  DOI：

  10.1021/jm00158a013

文献信息

• 2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding
  作者：Claude Gueremy、Francois Audiau、Andre Uzan、Gerard Le Fur、Jean Michel Leger、Alain Carpy

  DOI：10.1021/jm00354a014

  日期：1982.12

  to be related to the 6-chloro-4-(N-methyl-piperazine)pyrimidine structure bearing a NH2 or NHR1 group as a substituent in position 2, provided that R1 was not an alpha branched alkyl group. The nature of the substituent in position 5 is also of importance for the affinity; 2-(benzylamino)-6-chloro-4-(N-methylpiperazino)-5-(methylthio)pyrimidine (22) is the most active member of the series. Molecular

  合成了一系列30个6-氯-2,4-二氨基嘧啶，并作为[3H]螺哌啶醇结合的抑制剂进行了体外测试。对多巴胺受体的亲和力表明与2位上带有NH2或NHR1基团作为取代基的6-氯-4-（N-甲基-哌嗪）嘧啶结构有关，但前提是R1不是α支链烷基组。5位的取代基的性质对于亲和力也很重要。2-（苄氨基）-6-氯-4-（N-甲基哌嗪子基）-5-（甲硫基）嘧啶（22）是该系列中最活跃的成员。通过X射线衍射和PCILO计算分析了三种化合物的分子结构。
• 4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for .alpha.2-adrenoceptors
  作者：Claude Gueremy、Francois Audiau、Christian Renault、Jesus Benavides、Andre Uzan、Gerard Le Fur

  DOI：10.1021/jm00158a013

  日期：1986.8

  A series of 4-amino-6-chloro-2-piperazinopyrimidines were synthesized and evaluated for their ability to interact with alpha 1- and alpha 2-adrenoceptors in vitro in binding assays using [3H]WB-4101, [3H]clonidine, and [3H]idazoxan as radioligands. Some compounds were also tested as inhibitors of [3H]spiroperidol binding. Several members of this series showed high and selective affinity for alpha 2-adrenoceptors. The nature of the 4-amino substituent seems to be the most critical factor in determining the potency at these receptors.