alpha-(4-Chlorophenyl)-7-methoxy-2-benzofuranmethanol | 82158-37-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: alpha-(4-Chlorophenyl)-7-methoxy-2-benzofuranmethanol
• 英文别名: (4-chlorophenyl)-(7-methoxy-1-benzofuran-2-yl)methanol
• CAS: 82158-37-0
• 化学式: C₁₆H₁₃ClO₃
• 分子量: 288.73
• InChiKey: BZOIBOMFRASZLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  42.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  alpha-(4-Chlorophenyl)-7-methoxy-2-benzofuranmethanol 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (4-chlorophenyl)(7-methoxy-1-benzofuran-2-yl)methanone
  参考文献：
  名称：

  A straightforward conversion of aurones to 2-benzoylbenzofurans: transformation of one class of natural products into another

  摘要：

  The naturally occurring aurones (2-benzylidene-3(2H)-benzofuran-3-ones) can be easily converted to another class of natural products 2-benzoylbenzo[b]furans, via an effective reduction, acid-mediated rearrangement, and oxidation cascade. This easy conversion was conducted without purification of intermediates. This straightforward conversion may be considered as a possible biosynthesis pathway of 2-benzoylbenzo[b]furans in plants. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.08.011
• 作为产物：
  描述：

  在 盐酸 、 sodium tetrahydroborate 、 水 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 1.5h， 生成 alpha-(4-Chlorophenyl)-7-methoxy-2-benzofuranmethanol
  参考文献：
  名称：

  A straightforward conversion of aurones to 2-benzoylbenzofurans: transformation of one class of natural products into another

  摘要：

  The naturally occurring aurones (2-benzylidene-3(2H)-benzofuran-3-ones) can be easily converted to another class of natural products 2-benzoylbenzo[b]furans, via an effective reduction, acid-mediated rearrangement, and oxidation cascade. This easy conversion was conducted without purification of intermediates. This straightforward conversion may be considered as a possible biosynthesis pathway of 2-benzoylbenzo[b]furans in plants. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.08.011

文献信息

• PESTELLINI, VITTORIO;GIOLITTI, ALESSANDRO;PASQUII, FRANCO;ABELLI, LUIGI;C+, EUR. J. MED. CHEM., 23,(1988) N 2, 203-206
  作者：PESTELLINI, VITTORIO、GIOLITTI, ALESSANDRO、PASQUII, FRANCO、ABELLI, LUIGI、C+

  DOI：——

  日期：——
• US4485112A
  申请人：——

  公开号：US4485112A

  公开（公告）日：1984-11-27
• A straightforward conversion of aurones to 2-benzoylbenzofurans: transformation of one class of natural products into another
  作者：Samir Yahiaoui、Marine Peuchmaur、Ahcène Boumendjel

  DOI：10.1016/j.tet.2011.08.011

  日期：2011.10

  The naturally occurring aurones (2-benzylidene-3(2H)-benzofuran-3-ones) can be easily converted to another class of natural products 2-benzoylbenzo[b]furans, via an effective reduction, acid-mediated rearrangement, and oxidation cascade. This easy conversion was conducted without purification of intermediates. This straightforward conversion may be considered as a possible biosynthesis pathway of 2-benzoylbenzo[b]furans in plants. (C) 2011 Elsevier Ltd. All rights reserved.