N,N-diethyl-2-[(Z)-[(4-methylsulfanylphenyl)-naphthalen-1-ylmethylidene]amino]oxyethanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-diethyl-2-[(Z)-[(4-methylsulfanylphenyl)-naphthalen-1-ylmethylidene]amino]oxyethanamine
• 化学式: C₂₄H₂₈N₂OS
• 分子量: 392.6
• InChiKey: NOXGNFLLBKAQJV-IZHYLOQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• ARYL NAPHTHYL METHANONE OXIME(S) AND PROCESS FOR PREPARATION THEREOF
  申请人：Council of Scientific and Industrial Research

  公开号：EP3039010B1

  公开（公告）日：2017-10-11
• US9994515B2
  申请人：——

  公开号：US9994515B2

  公开（公告）日：2018-06-12
• [EN] ARYL NAPHTHYL METHANONE OXIME(S) AND PROCESS FOR PREPARATION THEREOF<br/>[FR] OXIME(S) D'ARYL-NAPHTYL-MÉTHANONE ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2015029068A1

  公开（公告）日：2015-03-05

  The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof.