7-[(3-imidazol-1-ylpropylamino)methyl]-8-naphthalen-1-yloxy-N-(oxan-2-yloxy)oct-6-enamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-[(3-imidazol-1-ylpropylamino)methyl]-8-naphthalen-1-yloxy-N-(oxan-2-yloxy)oct-6-enamide
• 化学式: C₃₀H₄₀N₄O₄
• 分子量: 520.7
• InChiKey: UUBKUJFGMVLWGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  38
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Lee Cheol Hae

  公开号：US20100069630A1

  公开（公告）日：2010-03-18

  The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.

  本发明公开了一种新型萘氧基丙烯酰衍生物，用于抑制组蛋白去乙酰化酶的酶活性，从而有效抑制癌细胞增殖。
• Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same
  申请人：Korea Research Institute Of Chemical Technology

  公开号：EP2913322A2

  公开（公告）日：2015-09-02

  The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacctylase, leading effective suppression of cancer cell proliferation.

  本发明公开了新型萘氧丙烯基衍生物，可用于抑制组蛋白脱切酶的酶活性，从而有效抑制癌细胞增殖。
• US8053435B2
  申请人：——

  公开号：US8053435B2

  公开（公告）日：2011-11-08
• [EN] NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] DÉRIVÉS DE NAPHTHALÉNYLOXYPROPÉNYLE AYANT UNE ACTIVITÉ INHIBITRICE ENVERS L'HISTONE DÉSACÉTYLASE ET UNE COMPOSITION PHARMACEUTIQUE CONTENANT CEUX-CI
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2008054154A1

  公开（公告）日：2008-05-08

  [EN] The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.
  [FR] L'invention concerne de nouveaux dérivés naphthalényloxypropényle utiles pour inhiber l'activité enzymatique de l'histone désacétylase, conduisant à la suppression efficace de la prolifération de cellules cancéreuses.