1-Benzyl-5-methoxyindazole-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-Benzyl-5-methoxyindazole-3-carboxylic acid
• 英文别名: 1-benzyl-5-methoxyindazole-3-carboxylic acid
• 化学式: C₁₆H₁₄N₂O₃
• 分子量: 282.29
• InChiKey: YAEPMASYFAWXMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES<br/>[FR] PROCÉDÉS DE FABRICATION D'ACIDE 2-((1-BENZYL-1H-INDAZOL-3-YL)MÉTHOXY)-2-MÉTHYLPROPANOÏQUE ET DE SES DÉRIVÉS
  申请人：TRANSLATUM MEDICUS INC

  公开号：WO2020261158A1

  公开（公告）日：2020-12-30

  The invention in this disclosure is related to the processes of making Bindarit or derivatives thereof. Specifically, the present invention provides, in part, new processes for making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives. By way of non-limiting example, synthesis and purification processes of 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid are provided by the invention in this disclosure.

  本公开的发明涉及制备Bindarit或其衍生物的过程。具体来说，本发明部分提供了制备2-((1-苄基-1H-吲哚-3-基)甲氧基)-2-甲基丙酸及其衍生物的新工艺。举例而言，本公开的发明提供了2-((1-苄基-1H-吲哚-3-基)甲氧基)-2-甲基丙酸的合成和纯化过程。
• COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS
  申请人：Translatum Medicus, Inc.

  公开号：EP3310353A1

  公开（公告）日：2018-04-25
• PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
  申请人：Translatum Medicus Inc.

  公开号：EP3990433A1

  公开（公告）日：2022-05-04
• [EN] COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT ET LE DIAGNOSTIC DE TROUBLES OCULAIRES
  申请人：TRANSLATUM MEDICUS INC

  公开号：WO2016203313A1

  公开（公告）日：2016-12-22

  Compounds and compositions comprising an indazole type compound of formula I for use in the treatment of an ocular disorder, age-related macular degeneration and diabetic retinopathy, and methods thereof. Ocular disorders that may be treated include a diabetic eye disease, Vogt-Kayanagi-Harada disease, uveitis, uveitis associated with a systemic disease (i.e. lupus, Crohn's disease, rheumatoid arthritis and other diseases of immune origin), Bechet's disease, macular degeneration and diabetic retinopathy.