1-(2,5-difluorophenyl)-4-methylpiperazine | 1369381-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2,5-difluorophenyl)-4-methylpiperazine
• 英文别名: 1-(2,5-Difluorophenyl)-4-methylpiperazine
• CAS: 1369381-21-4
• 化学式: C₁₁H₁₄F₂N₂
• 分子量: 212.242
• InChiKey: CJRQJAKWIYGAAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 1,2,4-三氟苯 在 potassium carbonate 作用下， 反应 3.0h， 生成 1-(2,5-difluorophenyl)-4-methylpiperazine 、 1-(3,4-Difluorophenyl)-4-methylpiperazine
  参考文献：
  名称：

  Microwave-assisted amination from fluorobenzenes without catalyst and strong base

  摘要：

  A facile and versatile amination of fluorobenzenes has been developed in good to excellent yields under microwave irradiation in N-methylpyrrolidinone (NMP) without strong base and catalyst. The presence of additional halogen atom(s) enhanced the leaving ability of fluorine and meta fluorine gave higher activation than the ortho. It is remarkable that 1,2,3-trifluorobenzene, 1,2,4-trifluorobenzene and 1,2,4,5-tetrafluorobenzene can produce the regioselective mono-substituted products. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.12.001

文献信息

• 1,2,4-Triazolo [4,3-A] Pyridine Derivatives And Their Use For The Treatment Of Prevention Of Neurological And Psychiatric Disorders
  申请人：JANSSEN PHARMACEUTICALS, INC.

  公开号：US20170333426A1

  公开（公告）日：2017-11-23

  The present invention relates to methods of treating various central nervous system disorders using novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.
• US9737533B2
  申请人：——

  公开号：US9737533B2

  公开（公告）日：2017-08-22
• Microwave-assisted amination from fluorobenzenes without catalyst and strong base
  作者：Xiangguo Meng、Zhengyan Cai、Sa Xiao、Weicheng Zhou

  DOI：10.1016/j.jfluchem.2012.12.001

  日期：2013.2

  A facile and versatile amination of fluorobenzenes has been developed in good to excellent yields under microwave irradiation in N-methylpyrrolidinone (NMP) without strong base and catalyst. The presence of additional halogen atom(s) enhanced the leaving ability of fluorine and meta fluorine gave higher activation than the ortho. It is remarkable that 1,2,3-trifluorobenzene, 1,2,4-trifluorobenzene and 1,2,4,5-tetrafluorobenzene can produce the regioselective mono-substituted products. (C) 2012 Elsevier B.V. All rights reserved.