Lucifer Yellow VS dilithium salt

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Lucifer Yellow VS dilithium salt
• 英文别名: dilithium;6-amino-2-(3-ethenylsulfonylphenyl)-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonate
• 化学式: C20H12Li2N2O10S3
• 分子量: 550.5
• InChiKey: PSJNJVOFDDMXDP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.04
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  237
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  α-(4-aminobutyryloxy)pregn-4-ene-3,20-dione 、 Lucifer Yellow VS dilithium salt 生成 dilithium;2-[3-[2-[[4-[[(8S,9S,10R,11R,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl]oxy]-4-oxobutyl]amino]ethylsulfonyl]phenyl]-6-amino-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonate
  参考文献：
  名称：

  KIRK, DAVID N.;MILLER, BARRY W., J. CHEM. SOC. PERKIN TRANS. PT 1,(1988) N1, C. 2979-2982

  摘要：

  DOI：

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• [EN] PROBES FOR RAPID AND SPECIFIC DETECTION OF MYCOBACTERIA<br/>[FR] SONDES POUR LA DÉTECTION RAPIDE ET SPÉCIFIQUE DE MYCOBACTÉRIES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2017027062A1

  公开（公告）日：2017-02-16

  The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam- antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a β- lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.

  本公开的组成提供了新颖的生色团探针，用于特定地成像和检测分枝杆菌种类，尤其是对β-内酰胺类抗生素具有抗药性的种类。这些探针通过引入一种特定针对分枝杆菌中DprE1独特捕获机制的基团，从而实现对分枝杆菌的特异性。因此，只有表达β-内酰胺酶和DprE1的分枝杆菌种类才能激活笼状荧光探针，并通过功能性还原-共价结合机制将释放的荧光探针固定到细菌细胞上。这种探针的一个显著优点是，在其最敏感的情况下，能够实现单个分枝杆菌的检测。
• [EN] CHEMILUMINESCENT COMPOUNDS FOR MULTIPLEXING<br/>[FR] COMPOSÉS CHIMIOLUMINESCENTS POUR LE MULTIPLEXAGE
  申请人：ABBOTT LAB

  公开号：WO2021026402A1

  公开（公告）日：2021-02-11

  Disclosed herein are compounds, conjugates, and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.

  本文披露了一些化合物、结合物和方法，可用于检测样本中的分析物，如生物样本。
• [EN] ANTIBODY-POLYMER-DRUG CONJUGATES<br/>[FR] CONJUGUÉS ANTICORPS-POLYMÈRE-MÉDICAMENT
  申请人：UNIV UTAH RES FOUND

  公开号：WO2018071767A1

  公开（公告）日：2018-04-19

  Disclosed herein, are antibody-polymer-drug conjugates. The conjugate comprises a targeting moiety, one or more polymers, and one or more therapeutic agents. Also described herein, are compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文披露了抗体-聚合物-药物共轭物。该共轭物包括一个靶向基团、一个或多个聚合物和一个或多个治疗剂。本文还描述了包含这些共轭物的组合物、它们的制备方法以及使用这些共轭物或其组合物治疗各种疾病的方法。本摘要旨在作为在特定领域搜索的扫描工具，并不打算限制本发明。
• NOVEL TETRAAZA MACROCYCLIC COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF
  申请人：Yoo Jeong Soo

  公开号：US20120219495A1

  公开（公告）日：2012-08-30

  Provided are a cross-bridged tetraaza macrocyclic compound of a novel structure that can be used, for example, as a contrast agent for diagnostic imaging or a radiopharmaceutical and a method for preparing the same. The disclosed tetraaza macrocyclic compound is able to form a stable metal complex at a lower temperature and allows easy conjugation with a bioactive substance or a chemically active substance, when compared to the existing cross-bridged tetraaza macrocyclic compounds.

  提供的是一种新结构的交桥四氮杂大环化合物，可用作诊断成像的造影剂或放射性药物，以及一种制备该化合物的方法。所披露的四氮杂大环化合物能够在较低温度下形成稳定的金属配合物，并且与生物活性物质或化学活性物质相比，易于共轭。