N,N'-Tetramethyl-rosamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N,N'-Tetramethyl-rosamine
• 英文别名: [6-(dimethylamino)-9-phenylxanthen-3-ylidene]-dimethylazanium
• 化学式: C23H23N2O+
• 分子量: 343.4
• InChiKey: NGSXFKKYKWBNPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  15.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] CELL PERMEABLE, FLUORESCENT DYE<br/>[FR] COLORANT FLUORESCENT CAPABLE DE PÉNÉTRER DANS LES CELLULES
  申请人：ECOLE POLYTECH

  公开号：WO2013029650A1

  公开（公告）日：2013-03-07

  The invention pertains to a near-infrared fluorescent dye that is cell permeable and can be attached to selected proteins in living cells. The dye has the general formula (I) or its or its corresponding spirolactone (II) wherein Y is chosen from the group consisting of Si, Ge and Sn; R0 is -COO- or COOH; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are substituents, including hydrogen, independently from each other. The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows mini¬ mal background binding to biomolecules and biomolecular structures.

  该发明涉及一种近红外荧光染料，可以穿透细胞并附着于活细胞中的特定蛋白质。该染料具有一般式(I)或其相应的螺内酯(II)，其中Y选择自Si、Ge和Sn组成的群；R0为-COO-或COOH；R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15和R16为取代基，包括独立于彼此的氢。该染料(i)在600纳米以上的波长吸收和发射光；(ii)具有高光稳定性；(iii)具有高消光系数和高量子产率；(iv)可以与不同分子衍生化；(v)具有膜通透性，并显示对生物分子和生物分子结构的最小背景结合。
• Cell Permeable, Fluorescent Dye
  申请人：Ecole Polytechnique Federale de Lausanne (EPFL)

  公开号：US20140349282A1

  公开（公告）日：2014-11-27

  The invention pertains to a near-infrared fluorescent dye that is cell permeable and can be attached to selected proteins in living cells. The dye has the general formula or its corresponding spirolactone wherein Y is chosen from the group consisting of Si, Ge and Sn; R 0 is —COO − or COOH; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 and R 16 are substituents, including hydrogen, independently from each other. The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows minimal background binding to biomolecules and biomolecular structures.

  该发明涉及一种近红外荧光染料，该染料可穿透细胞，并可连接到活细胞中的特定蛋白质。 该染料具有一般化学式，或其相应的螺内酯化合物，其中Y选择自Si、Ge和Sn组成的组; R0为—COO−或COOH; R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15和R16为取代基，包括氢，彼此独立。 该染料(i)在600纳米以上吸收和发射光线; (ii)具有高光稳定性; (iii)具有高消光系数和高量子产率; (iv)可与不同分子衍生化; (v)具有膜渗透性，并对生物分子和生物分子结构显示最小的背景结合。
• FLUORESCENT POLYMERIC MATERIALS CONTAINING LIPID SOLUBLE RHODAMINE DYES
  申请人：LAM Joe Y.L.

  公开号：US20090072197A1

  公开（公告）日：2009-03-19

  Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.

  本发明披露了一种包括聚合物和一种或多种脂溶性罗丹明染料的荧光聚合物材料。该材料在制备多色微粒，特别是多色聚苯乙烯微粒方面特别有用，用于在单个样品中进行多重分析多种分析物。当受到光源的激发时，该材料会发出基于其中染料的性质、浓度和比例的独特发射。本发明还披露了制备和使用该材料的方法。
• CELL PERMEABLE, FLUORESCENT DYE
  申请人：Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO

  公开号：EP2748173B1

  公开（公告）日：2016-11-23
• NOVEL HEXATRIENE-BETA-CARBONYL COMPOUND
  申请人：Fukase Koichi

  公开号：US20100008857A1

  公开（公告）日：2010-01-14

  A label with which labeling is easy when labeling a molecule, i.e., a label that has a high reaction rate upon labeling and that produces a high reaction yield, as well as a precursor for the production of the label are provided. This is achieved by a hexatriene-β-carbonyl compound represented by Formula (I), a hexatriene-β-carbonyl compound represented by Formula (II), a hexatriene-β-carbonyl compound represented by Formula (III) and a hexatriene-β-carbonyl compound represented by Formula (IV). (wherein R 1 , R 2 , R 3 , R 4 , R 5 , X 1 , X 2 and Z are as defined in the specification)