Ethyl5-hydroxy-6,8-DI(oxiran-2-ylmethyl)-4-oxo-4H-chromene-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Ethyl5-hydroxy-6,8-DI(oxiran-2-ylmethyl)-4-oxo-4H-chromene-2-carboxylate
• 英文别名: ethyl 5-hydroxy-6,8-bis(oxiran-2-ylmethyl)-4-oxochromene-2-carboxylate
• 化学式: C₁₈H₁₈O₇
• 分子量: 346.3
• InChiKey: XWPORILQNZQHJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Amine condensation polymers as phosphate sequestrants
  申请人：Huval C. Chad

  公开号：US20080085259A1

  公开（公告）日：2008-04-10

  Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH 2 CH 2 — group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.

  本发明公开了一种聚合物或其生理上可接受的盐。该聚合物包括聚合的多功能胺单体。该胺单体包括至少两个胺基和至少两个通过—CH2CH2—基团连接的非环氮原子，但不包括乙二胺或二乙烯三胺。所公开的聚合物可用于结合需要此类治疗的受体中的阴离子。
• AMINE CONDENSATION POLYMERS AS PHOSPHATE SEQUESTRANTS
  申请人：Genzyme Corporation

  公开号：US20140044671A1

  公开（公告）日：2014-02-13

  Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH 2 CH 2 — group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.

  本发明涉及一种聚合物或其生理上可接受的盐。该聚合物包括聚合的多功能胺单体。该胺单体至少包括两个胺基和至少两个通过-CH2CH2-基团连接的无环氮原子，但该胺单体不包括乙二胺或二乙三胺。所述聚合物可用于在需要此类治疗的受体中结合阴离子。
• POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS
  申请人：Lees Inez

  公开号：US20130189215A1

  公开（公告）日：2013-07-25

  The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

  本发明提供了交联胺聚合物，可以有效地结合和清除胆汁酸从胃肠道中。这些胆酸结合聚合物或其制药组合物可以用于治疗各种疾病，包括高胆固醇血症，糖尿病，瘙痒，肠易激综合征-腹泻（IBS-D），胆酸吸收不良等。
• Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes
  申请人：GENZYME CORPORATION

  公开号：US11267924B2

  公开（公告）日：2022-03-08

  Polydiallylamine copolymers are copolymers comprising monomers of polydiallylamine and either polyvinlyamine or polyallylamine. Polydiallylamine copolymers are often crosslinked. The polydiallyamine copolymers are useful as pharmaceutical compositions and may be used in the treatment of type 2 diabetes and for mitigating the complications of type 2 diabetes.

  聚二烯丙基胺共聚物是由聚二烯丙基胺和聚乙烯醇胺或聚烯丙基胺单体组成的共聚物。聚二烯丙基胺共聚物通常是交联的。聚二烯丙基胺共聚物是有用的药物组合物，可用于治疗 2 型糖尿病和减轻 2 型糖尿病的并发症。
• AMINE DENDRIMERS
  申请人：GENZYME CORPORATION

  公开号：EP2049014A2

  公开（公告）日：2009-04-22