9-Methyl-3-propan-2-yl-3,9-diazabicyclo[4.2.1]nonane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂卓
• 英文名称: 9-Methyl-3-propan-2-yl-3,9-diazabicyclo[4.2.1]nonane
• 英文别名: 9-methyl-3-propan-2-yl-3,9-diazabicyclo[4.2.1]nonane
• 化学式: C₁₁H₂₂N₂
• 分子量: 182.31
• InChiKey: LIEIPTIWXHYIGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• TYROSINE KINASE INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20180008589A1

  公开（公告）日：2018-01-11

  Disclosed are imidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, Y and Z are as described herein. In certain embodiments, a compound disclosed herein inhibits a cellular TAM receptor, and can be used to treat disease mediated by or involving the TAM receptor family.