4-(5-nitro-1,3-dioxobenzo[de]isoquinolin-2-yl)-N-[4-(trifluoromethyl)phenyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(5-nitro-1,3-dioxobenzo[de]isoquinolin-2-yl)-N-[4-(trifluoromethyl)phenyl]benzenesulfonamide
• 化学式: C25H14F3N3O6S
• 分子量: 541.5
• InChiKey: AAXPHZSTFUDCNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• METHOD OF INHIBITING THE GROWTH OF HELICOBACTER PYLORI
  申请人：WANG WEN-CHING

  公开号：US20100305152A1

  公开（公告）日：2010-12-02

  The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds, which is an attractive target for the rational drug and herbicide design because it is essential in algae, higher plants, bacteria, and fungi, but absent from mammals. Thus, the present invention provides a method of inhibiting the growth of bacteria or fungi, especially Helicobacter pylori, through inhibiting enzymes in the shikimate pathway.
• SMALL ORGANIC MOLECULES FOR USE IN THE TREATMENT OF NEUROINFLAMMATORY DISORDERS
  申请人：THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER

  公开号：US20200046680A1

  公开（公告）日：2020-02-13

  This invention provides small organic molecules useful as therapeutics of neurodegenerative diseases. Small organic molecules that act as inhibitors of bone morphogenetic proteins (BMPs) are useful in the treatment of neuroinflammatory disorders, in particular multiple sclerosis.
• US8175860B2
  申请人：——

  公开号：US8175860B2

  公开（公告）日：2012-05-08