N'-hydroxy-2-(naphthalen-1-yloxymethyl)-N-pyrrolidin-3-yloct-2-enediamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N'-hydroxy-2-(naphthalen-1-yloxymethyl)-N-pyrrolidin-3-yloct-2-enediamide
• 化学式: C₂₃H₂₉N₃O₄
• 分子量: 411.5
• InChiKey: OXXIMKIBPBGDBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  99.7
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Lee Cheol Hae

  公开号：US20100069630A1

  公开（公告）日：2010-03-18

  The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.

  本发明公开了一种新型萘氧基丙烯酰衍生物，用于抑制组蛋白去乙酰化酶的酶活性，从而有效抑制癌细胞增殖。
• Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same
  申请人：Korea Research Institute Of Chemical Technology

  公开号：EP2913322A2

  公开（公告）日：2015-09-02

  The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacctylase, leading effective suppression of cancer cell proliferation.

  本发明公开了新型萘氧丙烯基衍生物，可用于抑制组蛋白脱切酶的酶活性，从而有效抑制癌细胞增殖。
• PHARMACEUTICAL COMPOSITION COMPRISING HDAC INHIBITOR AND ANTI-PD1 ANTIBODY OR ANTI PD-L1 ANTIBODY
  申请人：Crystalgenomics, Inc.

  公开号：EP4026544A1

  公开（公告）日：2022-07-13

  The present invention relates to a method for killing cancer cells by using a combination of an HDAC inhibitor and an anti-PD1 antibody or an anti PD-L1 antibody. The present invention can have an effective influence on: extending the survival of animals with cancer, tumors, tumor-related disorders and neoplastic diseases; inhibiting the growth of proliferative cells associated with neoplasms; or neoplastic degeneration.

  本发明涉及一种通过使用 HDAC 抑制剂和抗 PD1 抗体或抗 PD-L1 抗体的组合来杀死癌细胞的方法。本发明可对以下方面产生有效影响：延长癌症、肿瘤、肿瘤相关疾病和肿瘤性疾病动物的生存期；抑制与肿瘤相关的增殖细胞的生长；或肿瘤变性。
• ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP1945606A1

  公开（公告）日：2008-07-23
• US8053435B2
  申请人：——

  公开号：US8053435B2

  公开（公告）日：2011-11-08