2-(2-Bromophenyl)sulfanyl-3-chloronaphthalene-1,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2-Bromophenyl)sulfanyl-3-chloronaphthalene-1,4-dione
• 化学式: C₁₆H₈BrClO₂S
• 分子量: 379.7
• InChiKey: UIBGZIYOELBUPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] INHIBITORS OF FOOT AND MOUTH DISEASE VIRUS TARGETING THE RNA-DEPENDENT POLYMERASE ACTIVITY OF 3Dpol<br/>[FR] INHIBITEURS DU VIRUS DE LA FIÈVRE APHTEUSE CIBLANT L'ACTIVITÉ DE POLYMÉRASE DÉPENDANT DE L'ARN DE LA 3DPOL
  申请人：UNIV MISSOURI

  公开号：WO2012068390A1

  公开（公告）日：2012-05-24

  The present invention provides a novel method for treating, preventing or inhibiting Foot and Mouth Disease Virus. Also provided are several new classes of antiviral compounds for the treatment or prevention of Foot and Mouth Disease. The inventive antiviral compounds suppress the replication of Foot and Mouth Disease Virus RNA- Dependent RNA Polymerase (3Dpol) by blocking a preexisting binding pocket proximate to the active site of 3Dpol.