Cyto5F4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Cyto5F4
• 英文别名: (1,4-dioxonaphthalen-2-yl) 4-methylbenzoate
• 化学式: C₁₈H₁₂O₄
• 分子量: 292.3
• InChiKey: DYTZMZHJBZDCNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CHEMICAL AGENTS FOR THE PREVENTION OF INHIBITION OR TUMOR METASTASIS
  申请人：Bresnick Anne R.

  公开号：US20130090355A1

  公开（公告）日：2013-04-11

  The present invention provides methods of preventing or inhibiting tumor metastasis in a subject by administering a therapeutically effective amount of (1) a compound from a group of enumerated compounds, or a pharmaceutically acceptable salt thereof; (2) an agent that covalently modifies at least one cysteine residue of S100A4 protein; or (3) an agent that inhibits the interaction between S100A4 and myosin-IIA.
• [EN] METHOD AND COMPOSITIONS FOR INHIBITION OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR INHIBER LE FACTEUR D'INHIBITION DE LA MIGRATION DES MACROPHAGES (MIF)
  申请人：ECOLE POLYTECH

  公开号：WO2011066864A1

  公开（公告）日：2011-06-09

  The present invention relates to methods for inhibition of tautomerase activity of macrophage migration inhibitory factor (MIF). The invention further relates to substances for irreversibly covalently binding to MIF for inhibition of tautomerase activity.
• [EN] CHEMICAL AGENTS FOR THE PREVENTION OR INHIBITION OF TUMOR METASTASIS<br/>[FR] AGENTS CHIMIQUES POUR LA PRÉVENTION OU L'INHIBITION DE MÉTASTASES TUMORALES
  申请人：EINSTEIN COLL MED

  公开号：WO2011146101A1

  公开（公告）日：2011-11-24

  The present invention provides methods of preventing or inhibiting tumor metastasis in a subject by administering a therapeutically effective amount of (1) a compound from a group of enumerated compounds, or a pharmaceutically acceptable salt thereof; (2) an agent that covalently modifies at least one cysteine residue of S100A4 protein; or (3) an agent that inhibits the interaction between S100A4 and myosin-IIA.