5-Morpholin-4-ylsulfonylnaphthalen-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-Morpholin-4-ylsulfonylnaphthalen-1-amine
• 化学式: C₁₄H₁₆N₂O₃S
• 分子量: 292.36
• InChiKey: GGYZSDOOZZQKIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Nitrosation-Inducible Inhibitors Biological Macromolecules
  申请人：NUDLER Evgeny

  公开号：US20090186829A1

  公开（公告）日：2009-07-23

  Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: wherein R 1 and R 2 are hydrophobic or affinity groups and R 3 is selected from the group consisting of aminoacyl groups and peptidyl groups upon nitrosation. ANSA derivatives can be designed to selectively kill tumor cells and various pathogens, including bacteria, viruses, and fungi.