N,N'-naphthalene-1,5-diylbisbicyclo[4.1.0]heptane-7-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N'-naphthalene-1,5-diylbisbicyclo[4.1.0]heptane-7-carboxamide
• 英文别名: N-[5-(bicyclo[4.1.0]heptane-7-carbonylamino)naphthalen-1-yl]bicyclo[4.1.0]heptane-7-carboxamide
• 化学式: C₂₆H₃₀N₂O₂
• mdl: MFCD00340251
• 分子量: 402.5
• InChiKey: HUUNVNZQBWVCGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• SUBSTITUTED BICYCLO [4.1.0] HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES
  申请人：Looft Jan

  公开号：US20100189863A1

  公开（公告）日：2010-07-29

  The present invention relates to the use of a compound of the Formula (I) wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R 1 , R 2 , R 7 and R 8 and at least one further of the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are not hydrogen, wherein independently of one another also two of the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 can together denote a bridge with one or more bridge C atoms; Y 1 and Y 2 denote independently of one another hydrogen, methyl or ethyl; and R a and R b denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.

  本发明涉及使用式（I）化合物，其中：R1、R2、R3、R4、R5、R6、R7和R8各自独立地表示氢、具有1至6个碳原子的烷基基团或具有2至6个碳原子的烯基基团，但至少其中一个基团R1、R2、R7和R8以及至少另一个基团R1、R2、R3、R4、R5、R6、R7和R8不是氢，其中R1、R2、R3、R4、R5、R6、R7和R8的两个基团也可以独立地共同表示具有一个或多个桥接碳原子的桥；Y1和Y2各自独立地表示氢、甲基或乙基；以及Ra和Rb各自独立地表示氢、具有1至6个碳原子的烷基基团、具有2至6个碳原子的烯基基团或具有3至6个碳原子的环烷基团，作为食品香味物质。
• Ubiquitin ligase inhibitors and methods related thereto
  申请人：Alroy Iris

  公开号：US20070015768A1

  公开（公告）日：2007-01-18

  The application discloses compounds that inhibit ubiquitin ligase activity. The application further discloses antiviral compounds, anticancer compounds, and compounds useful for the treatment of neurological disorders.
• US7659277B2
  申请人：——

  公开号：US7659277B2

  公开（公告）日：2010-02-09
• US8487133B2
  申请人：——

  公开号：US8487133B2

  公开（公告）日：2013-07-16
• [EN] SUBSTITUTED BICYCLO[4.1.0]HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES<br/>[FR] Amides d'acide bicyclo[4.1.0]heptane-7-carboxylique substitués et dérivés de ces derniers en tant que substances aromatisantes pour les aliments
  申请人：SYMRISE GMBH & CO KG

  公开号：WO2008046895A1

  公开（公告）日：2008-04-24

  [EN] The present invention relates to the use of a compound of the Formula (I) wherein: R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R¹, R², R⁷ and R⁸ and at least one further of the radicals R¹, R², R³, R⁴, R⁵, R⁶, R⁷ a nd R⁸ are not hydrogen, wherein independently of one another also two of the radicals R¹, R², R³, R⁴, R⁵, R⁶, R⁷ a nd R⁸can together denote a bridge with one or more bridge C atoms; Y¹ and Y² denote independently of one another hydrogen, methyl or ethyl; and R^a and R^b denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.
  [FR] La présente invention concerne l'utilisation d'un composé de la formule (I) dans laquelle : R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ représentent dans chaque cas, indépendamment les uns des autres, de l'hydrogène, un radical alkyle comprenant 1 à 6 atomes de carbone, ou un radical alcényle comprenant 2 à 6 atomes de carbone, à condition qu'au moins un des radicaux R¹, R², R⁷ et R⁸ et au moins un autre des radicaux R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ ne soient pas de l'hydrogène. Deux des radicaux R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ _,