Disodium;8-hydroxy-6-sulfonaphthalene-1,3-disulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Disodium;8-hydroxy-6-sulfonaphthalene-1,3-disulfonate
• 英文别名: disodium;8-hydroxy-6-sulfonaphthalene-1,3-disulfonate
• 化学式: C10H6Na2O10S3
• 分子量: 428.3
• InChiKey: MZLBPOBYLYIXCZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.39
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  214
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• TRBD-Binding Effectors and Methods for Using the Same to Modulate Telomerase Activity
  申请人：Skordalakes Emmanuel

  公开号：US20100160260A1

  公开（公告）日：2010-06-24

  The present invention embraces compounds selected for interacting with the T-pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.
• Screening Method and Compounds for Modulating Telomerase Activity
  申请人：Skordalakes Emmanuel

  公开号：US20120309759A1

  公开（公告）日：2012-12-06

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY
  申请人：The Wistar Institute

  公开号：US20160067257A1

  公开（公告）日：2016-03-10

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• US8377992B2
  申请人：——

  公开号：US8377992B2

  公开（公告）日：2013-02-19
• US9234230B2
  申请人：——

  公开号：US9234230B2

  公开（公告）日：2016-01-12