4-amino-N'-[(2-methylnaphthalen-1-yl)methoxy]-1,2,5-oxadiazole-3-carboximidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-amino-N'-[(2-methylnaphthalen-1-yl)methoxy]-1,2,5-oxadiazole-3-carboximidamide
• 化学式: C₁₅H₁₅N₅O₂
• 分子量: 297.31
• InChiKey: PJOVDZHDBBINIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING MALARIA, CONTAINING COMPOUNDS THAT INHIBIT PLASMEPSIN II ACTIVITY, AND METHOD OF TREATING MALARIA USING THE SAME<br/>[FR] COMPOSITION PHARMACEUTIQUE POUR PRÉVENIR ET TRAITER LE PALUDISME, CONTENANT DES COMPOSÉS QUI INHIBENT L'ACTIVITÉ DE LA PLASMEPSINE II ET MÉTHODE DE TRAITEMENT DU PALUDISME À L'AIDE DE LADITE COMPOSITION
  申请人：UNIV NAT CHONNAM IND FOUND

  公开号：WO2009131384A2

  公开（公告）日：2009-10-29

  A pharmaceutical composition containing a compound that binds to active sites of plasmepsin II to inhibit activity, and a method of preventing and treating malaria, including administering an effective dose of the pharmaceutical composition to a mammal. The pharmaceutical composition of the invention contains at least one compound selected from the group consisting of an N- alkoxyamidine derivative, a guanidine derivative, an amide derivative, a urea or thiourea derivative, and N- (2-[3-(l,3 -benzodioxol- 5 -yl) - 3 -oxo- 1 -propene- 1 -yl] amino } phenyl)-4-nitrobenzene sul¬ fonamide. The compound contained in the pharmaceutical composition is used to prevent and treat malaria since it binds to active sites of plasmepsin II to inhibit activity. The compound is effective to malaria that is resistant to existing anti-malarial drugs.