6-庚炔-2,5-二胺 | 81645-70-7

• 分子结构分类: 有机化合物 - 乙炔化物
• 中文名称: 6-庚炔-2,5-二胺
• 中文别名: 1H-吡喃联氮基[1,2-a]喹喔啉,2,3,4,4a,5,6-六氢-
• 英文名称: 1-ethynyl-4-methyl-1,4-butanediamine
• 英文别名: Methylacetylenic putrescine；6-heptyne-2,5-diamine；hept-6-yne-2,5-diamine
• CAS: 81645-70-7
• 化学式: C₇H₁₄N₂
• mdl: MFCD19204084
• 分子量: 126.202
• InChiKey: QIADQCOYEFCREQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Improvement process for debrominative rearrangements
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0370153A1

  公开（公告）日：1990-05-30

  This invention relates to an improvement in the standard procedures involving a debrominative rearrangement reaction of a terminal dibromoolefin with activated magnesium in tetrahydrofuran.

  这项发明涉及改进标准程序，涉及将末端二溴烯与四氢呋喃中活化的镁进行去溴重排反应。
• Nucleosides and their use as antineoplastic agents
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0211354A2

  公开（公告）日：1987-02-25

  This invention relates to the use of certain nucleosides in the treatment of neoplasms, either alone or in conjunctive therapy with ornithine decarboxylase inhibitors and/or S-­adenosylmethionine decarboxylase inhibitors.

  本发明涉及某些核苷在治疗肿瘤中的应用，可以单独使用，也可以与鸟氨酸脱羧酶抑制剂和/或 S-腺苷蛋氨酸脱羧酶抑制剂联合使用。
• Ghilanten: antimetastatic principle from the south american leech, haementeria ghilianii
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0404055A1

  公开（公告）日：1990-12-27

  A method for the inhibition of tumor metastases is described herein. The method makes use of the administration of an antimetastatic factor isolated from the leech Haementeria ghilianii.

  本文描述了一种抑制肿瘤转移的方法。该方法利用了一种从水蛭 Haementeria ghilianii 中分离出来的抗转移因子。
• Topical composition for follicular delivery of an ornithine decarboxylase inhibitor
  申请人：——

  公开号：US20030053973A1

  公开（公告）日：2003-03-20

  Polyethylene glycol ethers of alkyl alcohols having the general formula CH 3 (CH 2 ) x CH 2 (OCH 2 CH 2 ) n OH wherein x is 8 to 20 (of which ceteareth-20, steareth-20 and steareth-100 are preferred), poloxamer 185, poloxamer 407, N,N-dimethyl dodecylamine N-oxide, and mixtures thereof, are employed to increase follicular delivery and/or follicular residence time of certain water soluble ornithine decarboxylase inhibitors of which 2(difluoromethyl)-2,5-diamino pentanoic acid and its pharmaceutically acceptable salts, hydrates, optical enantiomers and racemic mixture are preferred.

  通式为 CH 3 (CH 2 ) x CH 2 (OCH 2 CH 2 ) n OH，其中 x 为 8 至 20（优选 ceteareth-20、steareth-20 和 steareth-100）、poloxamer 185、poloxamer 407、N,N-二甲基十二胺 N-氧化物及其混合物、可用于增加某些水溶性鸟氨酸脱羧酶抑制剂的毛囊递送和/或毛囊停留时间，其中优选 2（二氟甲基）-2,5-二氨基戊酸及其药学上可接受的盐、水合物、光学对映体和外消旋混合物。
• Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents
  申请人：Maziasz Timothy

  公开号：US20050026902A1

  公开（公告）日：2005-02-03

  The present invention provides compositions and methods for the treatment of human immunodeficiency virus (HIV) infection as well as HIV associated diseases and related disorders. More particularly, the invention provides a combination therapy for the treatment of HIV infection as well as HIV associated diseases and related disorders comprising the administration to a subject of an anti-human immunodeficiency virus agent in combination with a cyclooxygenase-2 selective inhibitor or an isomer or a pharmaceutically acceptable salt, ester, or prodrug thereof.

  本发明提供了治疗人类免疫缺陷病毒（HIV）感染以及HIV相关疾病和相关紊乱的组合物和方法。更具体地说，本发明提供了一种治疗HIV感染以及HIV相关疾病和相关紊乱的组合疗法，包括向受试者施用抗人类免疫缺陷病毒制剂与环氧化酶-2选择性抑制剂或其异构体或其药学上可接受的盐、酯或原药组合。