5-(2,3-dihydro-1H-perimidine-2-yl)-2-methoxyphenol | 305352-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(2,3-dihydro-1H-perimidine-2-yl)-2-methoxyphenol
• 英文别名: VPC-4；ZINC04420173；5-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxyphenol
• CAS: 305352-56-1
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.337
• InChiKey: GTHNINLDBDANIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  53.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异香兰素 、 1,8-二氨基萘 以 乙醇 为溶剂， 以87 %的产率得到5-(2,3-dihydro-1H-perimidine-2-yl)-2-methoxyphenol
  参考文献：
  名称：

  Highly Efficient Visible Light Assisted Synthesis of Perimidines under Catalyst-free and Room Temperature Conditions

  摘要：

  摘要： 可见光作为一种廉价且随时可用的能源，已在有机化学中崭露头角。能量转移反应是未来开发实用的、可扩展的工业反应的方向，并具有多种环境效益。通过 1,8-二氨基萘和芳基醛的环缩合反应，建立了一种简便、经济和可见光（CFL）诱导的包脒合成方法，并在短时间内获得了极好的收率（87%-100%）。该方法具有多个优点：高效、绿色、原子经济性高、无需外部加热和其他仪器设置、无需催化剂、无需繁琐的纯化过程。

  DOI：

  10.2174/1570178620666221223093203

文献信息

• Compositions and Methods Related to Fructosamine-3-Kinase Inhibitors
  申请人：Schwartz Michael

  公开号：US20100297046A1

  公开（公告）日：2010-11-25

  The invention relates to compounds and methods for inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin, by way of fructosamine-3-kinase inhibition, thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.
• [EN] COMPOSITIONS AND METHODS RELATED TO FRUCTOSAMINE-3-KINASE INHIBITORS<br/>[FR] COMPOSITIONS ET PROCEDES RELATIFS AUX INHIBITEURS DE LA FRUCTOSAMINE-3-KINASE
  申请人：DYNAMIS THERAPEUTICS INC

  公开号：WO2007117394A2

  公开（公告）日：2007-10-18

  [EN] The invention relates to compounds and methods for inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin, by way of fructosamine-3-kinase inhibition, thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.
  [FR] La présente invention concerne des composés et procédés d'inhibition de la production et de la fonction de la 3-désoxyglucosone et d'autres sucres alpha-dicarbonyle dans la peau, par le biais de l'inhibition de la fructosamine-3-kinase, ce qui permet de traiter ou de prévenir divers troubles, maladies ou états pathologiques. En outre, la présente invention concerne le traitement de divers troubles, maladies ou états pathologiques associés à ou induits par le stress oxydant, car 3DG induit des ROS (espèces oxygénées radicalaires) et des AGE (produits terminaux de glycation), lesquels sont associés à la réponse inflammatoire provoquée par le stress oxydant.
• [EN] INHIBITORS OF ANDROGEN RECEPTOR ACTIVATION FUNCTION-2 (AF2) AS THERAPEUTICS AND METHODS FOR THEIR USE<br/>[FR] INHIBITEURS DE FONCTION D'ACTIVATION DE RÉCEPTEUR D'ANDROGÈNE 2 (AF2) EN TANT QU'AGENTS THÉRAPEUTIQUES ET PROCÉDÉS POUR LEUR UTILISATION
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2013023300A1

  公开（公告）日：2013-02-21

  This invention provides compound having a structure of Formula ((IA)/(IB)) or Formula ((IIA)/(IIB)) or Formula (III): Formula (IA) or Formula (IB) or Formula (IIA) (IIB) or (III). Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.