1-(4-Benzylpiperazin-1-yl)-3-naphthalen-2-yloxypropan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(4-Benzylpiperazin-1-yl)-3-naphthalen-2-yloxypropan-2-ol
• 化学式: C₂₄H₂₈N₂O₂
• 分子量: 376.5
• InChiKey: BMPFNRPQIZBOTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• COMPOUNDS FOR MODULATING T-CELLS
  申请人：Trede Nikolaus S.

  公开号：US20080293739A1

  公开（公告）日：2008-11-27

  Disclosed are compounds and compositions that modulate T-cells. Such compounds can be used to treat T-cell mediated disease like T-ALL, rheumatoid arthritis, multiple sclerosis, and graft-vs-host disease (GvHD), to name but a few. The compounds have a general structure as shown in Formula I. Ar 1 -L-Ar 2 I wherein Ar 1 and Ar 2 , are independent of one another, a substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl; and L is a bond or a linker spanning two, three, four, or five atoms.
• US8039505B2
  申请人：——

  公开号：US8039505B2

  公开（公告）日：2011-10-18
• [EN] METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS<br/>[FR] PROCÉDÉS D'UTILISATON DE COMPOSÉS PIPÉRAZINE DANS LE TRAITEMENT DE MALADIES OU ÉTATS MÉDIÉS PAR LE CANAL SODIUM
  申请人：XENON PHARMACEUTICALS INC

  公开号：WO2008147864A2

  公开（公告）日：2008-12-04

  [EN] This invention is directed to piperazine compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
  [FR] L'invention concerne des composés pipérazine, tels que des stéréoisomères, des énantiomères, des tautomères et des mélanges de ces derniers, ou des sels, solvates ou promédicaments pharmaceutiquement acceptables de ces derniers, qui sont destinés au traitement et/ou à la prévention de maladies ou états médiés par le canal sodium, comme la douleur.