N-[(4-methoxyphenyl)methyl]-1-(naphthalen-1-ylmethyl)piperidine-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(4-methoxyphenyl)methyl]-1-(naphthalen-1-ylmethyl)piperidine-4-carboxamide
• 化学式: C₂₅H₂₈N₂O₂
• 分子量: 388.5
• InChiKey: FPSLGKGTZSFLOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Peptidomimetics for the treatment of coronavirus and picornavirus infections
  申请人：Emory University

  公开号：US11207370B2

  公开（公告）日：2021-12-28

  Compounds, compositions and methods for preventing, treating or curing a coronavirus, picornavirus, and/or hepeviridae virus infection in human subjects or other animal hosts. Specific viruses that can be treated include enteroviruses. In one embodiment, the compounds can be used to treat an infection with a severe acute respiratory syndrome virus, such as human coronavirus 229E, SARS, MERS, SARS-CoV-1 (OC43), and SARS-CoV-2. In another embodiment, the methods are used to treat a patient co-infected with two or more of these viruses, or a combination of one or more of these viruses and norovirus.

  用于预防、治疗或治愈人类或其他动物宿主冠状病毒、皮卡病毒和/或肝病毒科病毒感染的化合物、组合物和方法。可治疗的特定病毒包括肠道病毒。在一个实施方案中，化合物可用于治疗严重急性呼吸系统综合征病毒感染，如人冠状病毒 229E、SARS、MERS、SARS-CoV-1（OC43）和 SARS-CoV-2。在另一个实施方案中，这些方法用于治疗合并感染两种或两种以上这些病毒的患者，或合并感染一种或多种这些病毒和诺如病毒的患者。
• PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS
  申请人：Emory University

  公开号：US20210008150A1

  公开（公告）日：2021-01-14

  Compounds, compositions and methods for preventing, treating or curing a coronavirus, picornavirus, and/or hepeviridae virus infection in human subjects or other animal hosts. Specific viruses that can be treated include enteroviruses. In one embodiment, the compounds can be used to treat an infection with a severe acute respiratory syndrome virus, such as human coronavirus 229E, SARS, MERS, SARS-CoV-1 (OC43), and SARS-CoV-2. In another embodiment, the methods are used to treat a patient co-infected with two or more of these viruses, or a combination of one or more of these viruses and norovirus.
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF SARS-COV-2<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE SARS-COV-2
  申请人：UNIV GEORGIA

  公开号：WO2021189046A1

  公开（公告）日：2021-09-23

  Compositions and method of reducing activity of a SARS-CoV-2 PLpro are provided. The methods typically include contacting a SARS-CoV-2 PLpro with an effective amount of a PLpro inhibitor compound to reduce the activity of the a SARS-CoV-2 PLpro. In some embodiments, the activity that is reduced includes or consists of cleavage of a SARS-CoV-2 polypeptide, deubiquitination, deISGylation, or a combination thereof. In some embodiments, the activity that is reduced includes or consists of suppression of a host innate immune response. In some embodiments, the contacting occurs in a subject in vivo. The subject can have a SARS-CoV-2 infection. Thus, methods of treating a SARS-CoV-2 infection are also provided.