methyl N-(9H-xanthen-9-ylcarbonyl)leucinate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: methyl N-(9H-xanthen-9-ylcarbonyl)leucinate
• 英文别名: methyl 4-methyl-2-(9H-xanthene-9-carbonylamino)pentanoate
• 化学式: C₂₁H₂₃NO₄
• 分子量: 353.4
• InChiKey: XTRQRUQJHPZQTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method for Controlling Hematophagous or Sap-Feeding Arthropods
  申请人：Board of Supervisors of Lousiana State University and Agricultural and Mechanical College

  公开号：US20190320655A1

  公开（公告）日：2019-10-24

  Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids.