(R)-(+)-N-dantoylphenylalaninol | 72782-24-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-(+)-N-dantoylphenylalaninol
• 英文别名: 5-(dimethylamino)-N-[(2R)-1-hydroxy-3-phenylpropan-2-yl]naphthalene-1-carboxamide
• CAS: 72782-24-2
• 化学式: C₂₂H₂₄N₂O₂
• 分子量: 348.445
• InChiKey: WCSIHYYZHVZUJV-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  D-苯丙氨醇 、 5-Dimethylamino-1-naphthalin-carbonsaeurechlorid 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以27%的产率得到(R)-(+)-N-dantoylphenylalaninol
  参考文献：
  名称：

  Synthesis and study of conformationally defined enantiomers of local anesthetics and conformationally defined enantiomers of fluorescent dyes designed to label electrically excitable membranes

  摘要：

  Conformationally defined enantiomeric local anesthetics and fluorescent dyes were synthesized. Neither the local anesthetics nor the fluorescent probes showed stereospecificity in interacting with nerve membranes. The fluorescence signals generated by the dyes showed excellent correlation with the time course and shape of the nerve action potential.

  DOI：

  10.1021/jm00177a014

文献信息

• MAUTNER H. G.; LORENC C.; QUAIN P.; MARQUIS J. K.; TASAKI ICHIJI, J. MED. CHEM., 1980, 23, NO 3, 282-285
  作者：MAUTNER H. G.、 LORENC C.、 QUAIN P.、 MARQUIS J. K.、 TASAKI ICHIJI

  DOI：——

  日期：——
• Synthesis and study of conformationally defined enantiomers of local anesthetics and conformationally defined enantiomers of fluorescent dyes designed to label electrically excitable membranes
  作者：Henry G. Mautner、Carol Lorenc、Paul Quain、Judith K. Marquis、Ichiji Tasaki

  DOI：10.1021/jm00177a014

  日期：1980.3

  Conformationally defined enantiomeric local anesthetics and fluorescent dyes were synthesized. Neither the local anesthetics nor the fluorescent probes showed stereospecificity in interacting with nerve membranes. The fluorescence signals generated by the dyes showed excellent correlation with the time course and shape of the nerve action potential.