(1Z)-N'-{[(4-methylphenyl)acetyl]oxy}-2-(naphthalen-1-yl)ethanimidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (1Z)-N'-{[(4-methylphenyl)acetyl]oxy}-2-(naphthalen-1-yl)ethanimidamide
• 英文别名: [(Z)-(1-amino-2-naphthalen-1-ylethylidene)amino] 2-(4-methylphenyl)acetate
• 化学式: C₂₁H₂₀N₂O₂
• 分子量: 332.4
• InChiKey: DVNCJGNQQQSNNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Small molecule ferroptosis inducers
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US10947188B2

  公开（公告）日：2021-03-16

  The present invention provides, inter alia, a compound according to formula (I): Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.

  本发明特别提供了一种符合式 (I) 的化合物： 还提供了含有药学上可接受的载体和根据本发明的化合物的组合物。此外，还提供了调节细胞中 GPX4 的方法和诱导细胞中铁细胞凋亡的方法。
• SMALL MOLECULE FERROPTOSIS INDUCERS
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20190315681A1

  公开（公告）日：2019-10-17

  The present invention provides, inter alia, a compound according to formula (I): Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.