N-1-adamantyl-N'-(2,3-dihydro-1,4-benzodioxin-6-yl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: N-1-adamantyl-N'-(2,3-dihydro-1,4-benzodioxin-6-yl)urea
• 英文别名: 1-(1-adamantyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)urea
• 化学式: C₁₉H₂₄N₂O₃
• 分子量: 328.4
• InChiKey: KGNFUQPAMPXCDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  59.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• SOLUBLE EPOXIDE HYDROLASE INHIBITORS
  申请人：Gless, JR. Richard D.

  公开号：US20090082395A1

  公开（公告）日：2009-03-26

  Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetic-related diseases.
• [EN] SOLUBLE EPOXIDE HYDROLASE INHIBITORS<br/>[FR] INHIBITEURS D'ÉPOXYDE HYDROLASE SOLUBLE
  申请人：ARETE THERAPEUTICS INC

  公开号：WO2009035951A2

  公开（公告）日：2009-03-19

  Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetic-related diseases.