6-[3-[2-(3-Bicyclo[3.3.1]nonanyl)ethyl]-4-methoxyphenyl]naphthalene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-[3-[2-(3-Bicyclo[3.3.1]nonanyl)ethyl]-4-methoxyphenyl]naphthalene-2-carboxylic acid
• 英文别名: 6-[3-[2-(3-bicyclo[3.3.1]nonanyl)ethyl]-4-methoxyphenyl]naphthalene-2-carboxylic acid
• 化学式: C₂₉H₃₂O₃
• 分子量: 428.6
• InChiKey: ZCDDNBNRUYSPGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS
  申请人：GRI BIO, INC.

  公开号：US20210169909A1

  公开（公告）日：2021-06-10

  The present embodiments relate to methods for the prevention and treatment of inflammatory conditions such as alcoholic liver disease (ALD). More specifically the present embodiments relate to the prevention and treatment of ALD through the administration of an Retinoic Acid Receptor (RAR) agonist. Some embodiments relate to use of tazarotene in the prevention and treatment of alcohol-induced liver injury, alcohol-related liver disease, fatty liver disease, hepatic steatosis, alcoholic hepatitis or alcoholic cirrhosis.