(2S,3S,4S,5R)-3,4,5-trihydroxy-6-[4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenoxy]oxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (2S,3S,4S,5R)-3,4,5-trihydroxy-6-[4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenoxy]oxane-2-carboxylic acid
• 化学式: C₂₄H₂₈O₈
• 分子量: 444.5
• InChiKey: LJMPVHCKUXKZAV-YTXXKCOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Use of UGT inhibitors to increase bioavailability
  申请人：——

  公开号：US20030215462A1

  公开（公告）日：2003-11-20

  Methods for increasing the bioavailability of certain orally administered pharmaceutical compounds by the coadministration of inhibitors of UDP-glucuronosyltransferase (UGT) are disclosed. Particular combinations of UGT inhibitors and pharmaceutical compound are described.

  本研究公开了通过联合使用 UDP-葡萄糖醛酸转移酶（UGT）抑制剂来提高某些口服药物的生物利用度的方法。文中描述了 UGT 抑制剂和药物化合物的特定组合。
• Preparation for the application of agents in mini-droplets
  申请人：Cevc Gregor

  公开号：US20070042030A1

  公开（公告）日：2007-02-22

  The invention relates to a preparation for the application of agents in the form of minuscule droplets of fluid, in particular provided with membrane-like structures consisting of one or several layers of amphiphilic molecules, or an amphiphilic carrier substance, in particular for transporting the agent into and through natural barriers such as skin and similar materials. The preparation contains a concentration of edge active substances which amounts to up to 99 mol-% of the agent concentration which is required for the induction of droplet solubilization. Such preparations are suitable, for example, for the non-invasive applications of antidiabetics, in particular of insulin. The invention, moreover, relates to the methods for the preparation of such formulations.
• US6165500A
  申请人：——

  公开号：US6165500A

  公开（公告）日：2000-12-26
• [EN] USE OF UGT INHIBITORS TO INCREASE BIOAVAILABILITY<br/>[FR] UTILISATION D'INHIBITEURS D'UGT AFIN D'AUGEMENTER LA BIODISPONIBILITE
  申请人：AVMAX INC

  公开号：WO2003055494A1

  公开（公告）日：2003-07-10

  Methods for increasing the bioavailability of certain orally administered pharmaceutical compounds by the coadministration of inhibitors of UDP - glucuronosyltransferase (UGT) are disclosed. Particular combinations of UGT inhibitors and pharmaceutical compound are described.