4-(2,3-Dihydro-1,4-benzodioxin-6-ylmethylidene)hex-2-enoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 4-(2,3-Dihydro-1,4-benzodioxin-6-ylmethylidene)hex-2-enoic acid
• 英文别名: 4-(2,3-dihydro-1,4-benzodioxin-6-ylmethylidene)hex-2-enoic acid
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.28
• InChiKey: SHJUSGHXHWLLSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Aromatic amides as potentiators of bioefficacy of anti-infective drugs
  申请人：Koul Surrinder

  公开号：US20070004645A1

  公开（公告）日：2007-01-04

  The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

  本发明涉及芳香取代的戊二烯酸酰胺及其在芳香酰胺的特定量的组合中的使用，即4-烷基-5-(取代苯基)-2(E),4(E)-戊二烯酸酰胺，其几何异构体或其二氢或四氢衍生物，以及一种抗感染药物，有助于增强抗感染药物的生物功效。本发明的组合物在治疗某些感染和疾病方面非常有用，可以在抑制微生物菌株生长所需的抗感染剂浓度较低的情况下发挥作用，并且还可以在减少微生物的抗药性方面发挥作用。
• AROMATIC AMIDES AS POTENTIATORS OF BIOEFFICACY OF ANTI-INFECTIVE DRUGS
  申请人：Council Of Scientific and Industrial Research

  公开号：US20140073595A1

  公开（公告）日：2014-03-13

  The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

  本发明涉及芳香基取代的戊二烯酸酰胺及其在特定量的芳香酰胺，即4-烷基-5-（取代苯基）-2（E），4（E）-戊二烯酸酰胺，其几何异构体或其二氢或四氢衍生物和抗感染药物的组合物中的使用，有助于增强抗感染药物的生物功效。本发明的组合物对于治疗某些感染和疾病有用，可在抑制微生物菌株生长所需的抗感染剂浓度较低的情况下发挥作用，并且还可在减少微生物的耐药性方面应用。
• US8580752B2
  申请人：——

  公开号：US8580752B2

  公开（公告）日：2013-11-12
• US9073860B2
  申请人：——

  公开号：US9073860B2

  公开（公告）日：2015-07-07
• [EN] AROMATIC SUBSTITUTED PENTADIENOIC ACID AMIDE FOR COMBINATION WITH ANTI-INFECTIVE DRUGS<br/>[FR] AMIDE AROMATIQUE SUBSTITUE DE L'ACIDE PENTADIENOIQUE DESTINE A ETRE ASSOCIE AVEC DES ANTI-INFECTIEUX
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2006103527A1

  公开（公告）日：2006-10-05

  [EN] The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.
  [FR] La présente invention se rapporte à des amides aromatiques substitués de l'acide pentadiénoïques et leur utilisation en association avec des quantités spécifiques d'amides aromatiques, à savoir les amides de l'acide pentadiénoïque 4-alkyl-5-(phényle substitué)-2(E), 4(E)-, ses isomères géométriques ou leurs dérivés dihydro ou tétrahydro ainsi qu'un agent anti-infectieux utiles dans la potentialisation de la bioefficacité d'un agent anti-infectieux. L'association selon la présente invention est utile dans le traitement de certaines infections et maladies à faible concentration d'anti-infectieux nécessaires pour inhiber la croissance des souches microbiennes et peut également trouver des applications dans la réduction de la résistance des micro-organismes.