1,2-diphenylethyl N-(5-hydroxypentyl)carbamate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1,2-diphenylethyl N-(5-hydroxypentyl)carbamate
• 化学式: C₂₀H₂₅NO₃
• 分子量: 327.4
• InChiKey: JXOHYXSHZYMWNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Vaccines against Streptococcus pneumoniae serotype 5
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US10596272B2

  公开（公告）日：2020-03-24

  The present invention relates to well-defined synthetic saccharides of general formula (I) that are related to the repeating unit of Streptococcus pneumoniae serotype 5 capsular polysaccharide and conjugates thereof. The conjugates and pharmaceutical compositions containing said conjugates are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae serotype 5. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.

  本发明涉及与肺炎链球菌血清 5 型荚膜多糖重复单元有关的通式（I）的定义明确的合成糖类及其共轭物。所述共轭物和含有所述共轭物的药物组合物可用于预防和/或治疗与肺炎链球菌相关的疾病，更具体地说，可用于预防和/或治疗与肺炎链球菌血清 5 型相关的疾病。此外，通式（I）的合成糖类可作为免疫学试验中的标记物，用于检测针对肺炎链球菌的抗体。
• VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 5
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften

  公开号：EP3303357A1

  公开（公告）日：2018-04-11
• [EN] VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 5<br/>[FR] VACCINS CONTRE LE SÉROTYPE 5 DE STREPTOCOCCUS PNEUMONIAE
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V

  公开号：WO2016198170A1

  公开（公告）日：2016-12-15

  The present invention relates to well-defined synthetic saccharides of general formula (I) that are related to the repeating unit of Streptococcus pneumoniae serotype 5 capsular polysaccharide and conjugates thereof. The conjugates and pharmaceutical compositions containing said conjugates are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae serotype 5. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.