5-Methyl-2-(2-naphthalen-1-ylethenyl)-4-piperidin-1-ylpyridine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-Methyl-2-(2-naphthalen-1-ylethenyl)-4-piperidin-1-ylpyridine
• 化学式: C₂₃H₂₄N₂
• 分子量: 328.4
• InChiKey: YSUQWGYQBVSXRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Substituted pyridine derivatives
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0264883A2

  公开（公告）日：1988-04-27

  A substituted pyridine derivative represented by the general formula herein R¹ represents a phenyl or naphthyl group which may optionally be substituted by a substituent selected from the class consisting of a hydroxyl group, lower alkyl groups, lower alkoxy groups, cycloalkyl groups, lower alkoxycarbonyl groups, a phenyl group and halogen atoms; X represents an oxygen atom, a sulfur atom, a carbonyl group, or a group of the formula -CH(OH)- or -N(Ra)- in which Ra is hydrogen atom or a lower alkyl group; Y represents a linear or branched lower alkylene group or a vinylene group which may optionally be substituted by a lower alkyl group, with the proviso that when X is an oxygen or sulfur atom, Y represents the lower alkylene group. R² and R³ are identical or different and each represents a hydrogen atom or a lower alkyl group; R⁴ represents a hydrogen atom, a lower alkoxy group, a cycloalkyloxy group, a lower alkylthio group, a cycloalkylthio group, an aryloxy group, an aralkyloxy group or a group of the formula in which Rb and Rc are identical or different and each represents a hydrogen atom or a lower alkyl group, or Rb and Rc, taken together, may form together with the adjacent nitrogen atom a 5- to 7-membered saturated heterocyclic ring which may optionally contain at least one additional hetero atom selected from the group con­sisting of oxygen, sulfur and nitrogen atoms and may optionally be substituted by a lower alkyl group; m and n are each 0 or 1, with the proviso that m and n are not 0 at the same time, or an acid addition salt thereof. This compound is useful as an antiulcer agent.

  通式如下的取代吡啶衍生物 其中 R¹ 代表苯基或萘基，可任选被选自羟基、低级烷基、低级烷氧基、环烷基、低级烷氧羰基、苯基和卤素原子的取代基取代；X 代表氧原子、硫原子、羰基或式-CH(OH)-或-N(Ra)-的基团，其中 Ra 为氢原子或低级烷基；Y 代表直链或支链低级亚烷基或乙烯基，可选择被低级烷基取代，但当 X 为氧原子或硫原子时，Y 代表低级亚烷基。R² 和 R³ 相同或不同，各自代表氢原子或低级烷基；R⁴ 代表氢原子、低级烷氧基、环烷氧基、低级烷硫基、环烷硫基、芳氧基、芳烷氧基或式 其中 Rb 和 Rc 相同或不同，且各自代表一个氢原子或一个低级烷基，或 Rb 和 Rc 合在一起，可与相邻的氮原子一起形成一个 5 至 7 元饱和杂环，该杂环可任选包含至少一个选自氧、硫和氮原子组成的组的额外杂原子，并可任选被一个低级烷基取代；m 和 n 各为 0 或 1，但 m 和 n 不能同时为 0，或其酸加成盐。该化合物可用作抗溃疡剂。
• JPH01131157A
  申请人：——

  公开号：JPH01131157A

  公开（公告）日：1989-05-24
• US4839353A
  申请人：——

  公开号：US4839353A

  公开（公告）日：1989-06-13