1-Benzoimidazol-1-yl-3-(naphthalen-1-yloxy)-propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Benzoimidazol-1-yl-3-(naphthalen-1-yloxy)-propan-2-ol
• 英文别名: 1-(1H-benzimidazol-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol；1-(benzimidazol-1-yl)-3-naphthalen-1-yloxypropan-2-ol
• 化学式: C₂₀H₁₈N₂O₂
• 分子量: 318.375
• InChiKey: FWMVJSKYEPWDQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  47.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(β-Hydroxy-γ-chlorpropyl)-benzimidazol 以71%的产率得到
  参考文献：
  名称：

  SAWLEWICZ J.; GRZYBOWSKI M., ACTA POL. PHARM., 1978, 35, NO 3, 273-280

  摘要：

  DOI：

文献信息

• Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof
  申请人：Schmidt Ann Marie

  公开号：US10265320B2

  公开（公告）日：2019-04-23

  Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

  本发明公开了氨基化合物、氨基化合物和杂环化合物。这些化合物可制备成药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的多种疾病，包括非限制性的糖尿病并发症、炎症、神经变性、肥胖症、癌症、缺血/再灌注损伤、心血管疾病和其他与 RAGE 活性有关的疾病。
• Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof
  申请人：Schmidt Ann Marie

  公开号：US10729695B2

  公开（公告）日：2020-08-04

  Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

  本发明公开了氨基化合物、氨基化合物和杂环化合物。这些化合物可制备成药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的多种疾病，包括非限制性的糖尿病并发症、炎症、神经变性、肥胖症、癌症、缺血/再灌注损伤、心血管疾病和其他与 RAGE 活性有关的疾病。
• AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF
  申请人：Schmidt Ann Marie

  公开号：US20150094307A1

  公开（公告）日：2015-04-02

  Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.
• US9364472B2
  申请人：——

  公开号：US9364472B2

  公开（公告）日：2016-06-14
• US9353078B2
  申请人：——

  公开号：US9353078B2

  公开（公告）日：2016-05-31