methyl 3,3,3-trifluoro-2-(6-methoxynaphthalen-2-yl)propanoate | 1206883-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: methyl 3,3,3-trifluoro-2-(6-methoxynaphthalen-2-yl)propanoate
• 英文别名: β,β,β-trifluoronaproxen methyl ester；Methyl 3,3,3-trifluoro-2-(6-methoxynaphthalen-2-yl)propanoate
• CAS: 1206883-70-6
• 化学式: C₁₅H₁₃F₃O₃
• 分子量: 298.262
• InChiKey: RHAPAHCQDQKDJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-methoxy-α-(trifluoromethyl)-2-naphthalene acetic acid 、 三甲基硅烷化重氮甲烷 以 甲醇 、 乙醚 、 苯 为溶剂， 反应 0.5h， 生成 methyl 3,3,3-trifluoro-2-(6-methoxynaphthalen-2-yl)propanoate
  参考文献：
  名称：

  Synthesis of 2-aryl-3,3,3-trifluoropropanoic acids using electrochemical carboxylation of (1-bromo-2,2,2-trifluoroethyl)arenes and its application to the synthesis of β,β,β-trifluorinated non-steroidal anti-inflammatory drugs

  摘要：

  Electrochemical carboxylation of (1-bromo-2,2,2-trifluoroethyl)arenes resulted in an efficient fixation of carbon dioxide to give the corresponding 2-aryl-3,3,3-trifluoropropanoic acids in good yields, and the present reactions were successfully applied to the synthesis of beta,beta,beta-trifluorinated non-steroidal anti-inflammatory drugs (NSAIDs). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.11.053

文献信息

• Synthesis of 2-aryl-3,3,3-trifluoropropanoic acids using electrochemical carboxylation of (1-bromo-2,2,2-trifluoroethyl)arenes and its application to the synthesis of β,β,β-trifluorinated non-steroidal anti-inflammatory drugs
  作者：Yusuke Yamauchi、Shoji Hara、Hisanori Senboku

  DOI：10.1016/j.tet.2009.11.053

  日期：2010.1

  Electrochemical carboxylation of (1-bromo-2,2,2-trifluoroethyl)arenes resulted in an efficient fixation of carbon dioxide to give the corresponding 2-aryl-3,3,3-trifluoropropanoic acids in good yields, and the present reactions were successfully applied to the synthesis of beta,beta,beta-trifluorinated non-steroidal anti-inflammatory drugs (NSAIDs). (C) 2009 Elsevier Ltd. All rights reserved.