1-(3'-fluoro-4'-methylphenyl)naphthalene | 135227-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(3'-fluoro-4'-methylphenyl)naphthalene
• 英文别名: 1-(3-Fluoro-4-methylphenyl)naphthalene
• CAS: 135227-07-5
• 化学式: C₁₇H₁₃F
• 分子量: 236.289
• InChiKey: RAGRBAXYGYNFAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氟-4-碘甲苯 、 naphthalen-1-yl-lithium 生成 1-(3'-fluoro-4'-methylphenyl)naphthalene
  参考文献：
  名称：

  “动力学”高阶氰酸盐的受控“分解”：一条通往不对称联芳基的新途径

  摘要：

  通过控制两个关键的反应参数（温度和形成方式），可以生成空前的“动力学”高阶氰铜酸盐。在氧化conditins下，与以常规方式配制的结构相同的试剂相比，它们的化学性质是独特的。使用由ArLi，Ar'Li和CuCN制备的混合二芳基试剂ArAr'Cu（CN）Li 2，可以以很高的化学收率和可预测的方式实现非对称联芳基（Ar-Ar'）的显着选择性。

  DOI：

  10.1016/s0040-4020(01)88522-7

文献信息

• Synthesis of unsymmetrical biaryls via kinetic higher order cyanocuprates: scope, limitations, and spectroscopic insights
  作者：Bruce H. Lipshutz、Konstantin Siegmann、Emiliano Garcia、Frank Kayser

  DOI：10.1021/ja00073a051

  日期：1993.10

  Treatment of lower order arylcyanocuprates ArCu(CN)Li with 1 equiv of an aryllithium (Ar'Li) at temperatures around -125 o C leads to higher order reagents Ar(Ar')Cu(CN)Li 2 . Upon exposure of such reagents at this temperature to ground-state molecular oxygen, good yields of the unsymmetrical biaryl Ar-Ar' can be realized. Several different types of aryl ligands have been examined, including naphthalenes

  在 -125 o C 左右的温度下，用 1 当量的芳基锂 (Ar'Li) 处理低级芳基氰铜酸盐 ArCu(CN)Li 会产生高级试剂 Ar(Ar')Cu(CN)Li 2 。在该温度下将此类试剂暴露于基态分子氧后，可以实现不对称联芳基 Ar-Ar' 的良好产率。已经检查了几种不同类型的芳基配体，包括萘，以评估该方法的通用性。已经在 -130 o C 和更高温度下获得了三种不同铜酸盐的光谱数据（ 13 C NMR），以确定它们的动力学性质（如合成化学所示）是否可以通过物理方法证实
• Boronic acids and esters as inhibitors of fatty acid amide hydrolase
  申请人：Infinity Pharmaceuticals, Inc.

  公开号：EP2399585A1

  公开（公告）日：2011-12-28

  The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a provided compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH in a patient by administering a therapeutically effective amount of a compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof.

  本发明提供了式(I)、(II)或(III)所包含的化合物及其药物组合物。本发明还提供了通过向有需要的患者施用治疗有效量的所提供的式(I)、(II)或(III)化合物或其药物组合物来治疗FAAH介导的疾病、紊乱或病症的方法。此外，本发明还提供了通过向有需要的患者施用治疗有效量的式(I)、(II)或(III)化合物或其药物组合物来抑制患者体内FAAH的方法。
• "Kinetic" higher order cyanocuprates: applications to biaryl synthesis
  作者：Bruce H. Lipshutz、Konstantin Siegmann、Emiliano Garcia

  DOI：10.1021/ja00021a049

  日期：1991.10
• PYRENE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DIODE COMPRISING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20140183468A1

  公开（公告）日：2014-07-03

  A pyrene-based compound and an organic light-emitting diode including the pyrene-based compound are provided. The pyrene-based compound of Formula 1 above may emit blue light having high color purity. For example, an organic light-emitting diode including the pyrene-based compounds of the invention may emit blue light having a y coordinate with a color purity of 0.1 or less, for example, a color purity of 0.09 or less, which is near to the NTSC or sRGB specification. A thin film including the pyrene-based compounds of the invention may be highly amorphous, and thus may have improved electrical stability. Accordingly, an organic light-emitting diode including the pyrene-based compounds of the invention may have improved lifetime characteristics.