4,6,7-Trihydroxy-1,2,3,4-tetrahydroisochinolin | 50988-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 4,6,7-Trihydroxy-1,2,3,4-tetrahydroisochinolin
• 英文别名: 1,2,3,4-Tetrahydroisoquinoline-4,6,7-triol
• CAS: 50988-14-2
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: RNIMUEXSLJYHIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Infusion dosage form of norepinephrine
  申请人：SUN PHARMACEUTICAL INDUSTRIES LIMITED

  公开号：US11197838B2

  公开（公告）日：2021-12-14

  The present invention provides a ready to use stable aqueous dosage form of norepinephrine comprising an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, one or more sulfite antioxidants and an ion chelator. The present invention also provides an infusion container filled with an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, wherein the said solution is stable for a prolonged period of time and can be terminally sterilized by autoclaving.

  本发明提供了一种即用型去甲肾上腺素稳定水溶液剂型，包括去甲肾上腺素水溶液或其药学上可接受的盐、一种或多种亚硫酸盐抗氧化剂和离子螯合剂。本发明还提供了一种装有去甲肾上腺素水溶液或其药学上可接受的盐的输液容器，其中所述溶液可长期稳定使用，并可通过高压灭菌法进行最终灭菌。
• INFUSION DOSAGE FORM OF NOREPINEPHRINE
  申请人：SUN PHARMACEUTICAL INDUSTRIES LIMITED

  公开号：US20210038539A1

  公开（公告）日：2021-02-11

  The present invention provides a ready to use stable aqueous dosage form of norepinephrine comprising an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, one or more sulfite antioxidants and an ion chelator. The present invention also provides an infusion container filled with an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, wherein the said solution is stable for a prolonged period of time and can be terminally sterilized by autoclaving.
• [EN] INFUSION DOSAGE FORM OF NOREPINEPHRINE<br/>[FR] FORME POSOLOGIQUE D'INFUSION DE NORÉPINÉPHRINE
  申请人：SUN PHARMACEUTICAL IND LTD

  公开号：WO2021024237A1

  公开（公告）日：2021-02-11

  The present invention provides a ready to use stable aqueous dosage form of norepinephrine comprising an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, one or more sulfite antioxidants and an ion chelator. The present invention also provides an infusion container filled with an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, wherein the said solution is stable for a prolonged period of time and can be terminally sterilized by autoclaving.