(4-hydroxyphthalazin-1-yl)-(4-phenylpiperazin-1-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4-hydroxyphthalazin-1-yl)-(4-phenylpiperazin-1-yl)methanone
• 化学式: C₁₉H₁₈N₄O₂
• mdl: MFCD05031161
• 分子量: 334.4
• InChiKey: VOCACSIBMGPWHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  碘乙烷 、 (4-hydroxyphthalazin-1-yl)-(4-phenylpiperazin-1-yl)methanone 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以11 %的产率得到2-Ethyl-4-(4-phenylpiperazine-1-carbonyl)phthalazin-1-one
  参考文献：
  名称：

  PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE

  摘要：

  The disclosure herein provides compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) for killing cancer cell or inhibiting cancer cell proliferation. Further, the compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) are useful in methods of for the inhibition of cancer cell proliferation.

  公开号：

  WO2024108131A1
• 作为产物：
  描述：

  N-苯基哌嗪 、 4-羟基酞嗪-1-羧酸 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以25 %的产率得到(4-hydroxyphthalazin-1-yl)-(4-phenylpiperazin-1-yl)methanone
  参考文献：
  名称：

  PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE

  摘要：

  The disclosure herein provides compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) for killing cancer cell or inhibiting cancer cell proliferation. Further, the compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) are useful in methods of for the inhibition of cancer cell proliferation.

  公开号：

  WO2024108131A1

文献信息

• PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE
  申请人：[en]SOLEY THERAPEUTICS, INC.

  公开号：WO2024108131A1

  公开（公告）日：2024-05-23

  The disclosure herein provides compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) for killing cancer cell or inhibiting cancer cell proliferation. Further, the compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) are useful in methods of for the inhibition of cancer cell proliferation.