Bis(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4-carbonyl) butanedioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Bis(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4-carbonyl) butanedioate
• 英文别名: bis(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4-carbonyl) butanedioate
• 化学式: C₄₆H₂₆O₁₆
• 分子量: 834.7
• InChiKey: PEEJKGSSYUJMPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  62
• 可旋转键数：
  9
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  239
• 氢给体数：
  4
• 氢受体数：
  16

文献信息

• Shape memory particles for biomedical uses
  申请人：The Johns Hopkins University

  公开号：US10695427B2

  公开（公告）日：2020-06-30

  The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. Also provided are compositions, methods, and kits comprising nanoparticles and hypoxia-inducible factor (HIF) inhibitors with or without chemotherapeutic agents for inhibiting HIF activity in a patient and/or treating a hypoxia-associated disease or disorder.

  目前公开的主题提供了包含形状记忆颗粒的组合物、方法和试剂盒，这些组合物、方法和试剂盒可用于在患者体内给药和/或治疗疾病或失调。具体而言，本公开的形状记忆颗粒的形状变化可用于控制药物在患者体内的空间和/或时间输送。还提供了包含纳米颗粒和缺氧诱导因子（HIF）抑制剂的组合物、方法和试剂盒，无论是否含有化疗药物，均可用于抑制患者体内的 HIF 活性和/或治疗缺氧相关疾病或紊乱。
• SHAPE MEMORY PARTICLES FOR BIOMEDICAL USES
  申请人：The Johns Hopkins University

  公开号：EP3280761A1

  公开（公告）日：2018-02-14
• EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND THERAPEUTIC USES THEREOF
  申请人：Iovance Biotherapeutics, Inc.

  公开号：EP3931310A1

  公开（公告）日：2022-01-05
• Expansion of Tumor Infiltrating Lymphocytes From Liquid Tumors and Therapeutic Uses Thereof
  申请人：Iovance Biotherapeutics, Inc.

  公开号：US20220133795A1

  公开（公告）日：2022-05-05

  Methods of expanding peripheral blood lymphocytes (PBLs) from blood of patients with hematological malignancies, including lymphomas and leukemias, genetic modifications of expanded PBLs to incorporate chimeric antigen receptors, genetically modified T cell receptors, and other genetic modifications, and uses of such expanded and/or modified PBLs in the treatment of diseases such as cancers and hematological malignancies are disclosed herein.
• [EN] SHAPE MEMORY PARTICLES FOR BIOMEDICAL USES<br/>[FR] PARTICULES À MÉMOIRE DE FORME POUR USAGES BIOMÉDICAUX
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2016164458A1

  公开（公告）日：2016-10-13

  The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. Also provided are compositions, methods, and kits comprising nanoparticles and hypoxia-inducible factor (HIF) inhibitors for inhibiting HIF activity in a patient and/or treating a hypoxia-associated disease or disorder.