2-[4-(Tert-butyl)anilino]-3-chloronaphthoquinone

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[4-(Tert-butyl)anilino]-3-chloronaphthoquinone
• 英文别名: 2-(4-tert-butylanilino)-3-chloronaphthalene-1,4-dione
• 化学式: C₂₀H₁₈ClNO₂
• 分子量: 339.8
• InChiKey: HTEMGFMUAQKQCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS
  申请人：Scherzer Roni

  公开号：US20110224184A1

  公开（公告）日：2011-09-15

  The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.
• US9272993B2
  申请人：——

  公开号：US9272993B2

  公开（公告）日：2016-03-01
• [EN] NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS<br/>[FR] DÉRIVÉS DE NAPHTOQUINONE UTILES POUR LA PRÉVENTION DE DÉPÔTS AMYLOÏDES ET POUR LE TRAITEMENT DE MALADIES METTANT EN JEU L'AMYLOÏDOGENÈSE
  申请人：UNIV RAMOT

  公开号：WO2010026592A1

  公开（公告）日：2010-03-11

  The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.