1,2-Dimethyl-5-ethyl-piperidin | 6012-19-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,2-Dimethyl-5-ethyl-piperidin
• 英文别名: 3-Aethyl-1,6-dimethyl-piperidin；3-Ethyl-1,6-dimethyl-piperidin；N-Methyl-isocopellidin；5-Ethyl-1,2-dimethyl-piperidin；5-Aethyl-1,2-dimethyl-piperidin；5-ethyl-1,2-dimethyl-piperidine；N-Methyl-copellidin；5-Ethyl-1,2-dimethylpiperidine
• CAS: 6012-19-7
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: TTYZTSXCQYWNSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,2-Dimethyl-5-ethyl-piperidin 在 mercury(II) diacetate 、 溶剂黄146 作用下， 生成 3-乙基-1,6-二甲基-1,2,3,4-四氢-吡啶
  参考文献：
  名称：

  Unsaturated Amines. X. The Mercuric Acetate Route to Substituted Piperidines, Δ²-Tetrahydropyridines and Δ²-Tetrahydroanabasines

  摘要：

  DOI：

  10.1021/ja01576a056
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 silver(l) oxide 作用下， 生成 1,2-Dimethyl-5-ethyl-piperidin
  参考文献：
  名称：

  v.Braun; Schirmacher, Chemische Berichte, 1923, vol. 56, p. 1847

  摘要：

  DOI：

文献信息

• [EN] MODULATORS OF CULLIN 3 ADAPTOR KBTBD4 AS ANTI-CANCER COMPOUNDS<br/>[FR] MODULATEURS DE L'ADAPTATEUR DE CULLIN 3 KBTBD4 EN TANT QUE COMPOSÉS ANTICANCÉREUX
  申请人：UNIV MONTREAL

  公开号：WO2021119834A1

  公开（公告）日：2021-06-24

  It is provided the use of Pyrimido[4,5-B]indole derivatives as anti-cancer compounds, and more specifically the use of UM171 and its derivatives for treating cancer, by activating the CULLIN3-RING ubiquitin ligase complex which degrades RCOR1 which normally acts as the scaffolding protein for the RCOR1/LSD1 and HDAC2 complex, itself being dissociated in the presence of UM171. Thus UM171 acts like a molecular glue degrader, inhibiting HDACs, RCOR1, CoREST and LSD1 and resulting in an anti-cancer activity.

  提供使用嘧啶并[4,5-B]吲哚衍生物作为抗癌化合物，更具体地使用UM171及其衍生物来治疗癌症，通过激活CULLIN3-RING泛素连接酶复合物，降解通常作为RCOR1/LSD1和HDAC2复合物支架蛋白的RCOR1，本身在UM171存在时被解离。因此，UM171起到分子粘合蛋白降解剂的作用，抑制HDACs、RCOR1、CoREST和LSD1，从而产生抗癌活性。
• Quaternary ammonium salts of substituted pyrazoline compounds, their preparation and use as medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1749821A1

  公开（公告）日：2007-02-07

  The present invention relates to quaternary ammonium salts of substituted pyrazoline compounds of formula I, methods for their preparation, medicaments comprising theses compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及公式I的取代吡唑烯化合物的季铵盐，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。
• DERIVATIVES OF PYRAZOLE 3,5-CARBOXYLATES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
  申请人：FORICHER Yann

  公开号：US20100160377A1

  公开（公告）日：2010-06-24

  The invention relates to derivatives of pyrazole 3,5-carboxylates, of general formula (I): in which R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, V, W and n are as defined herein. The invention also relates to salts of these compounds as well as hydrates or of solvates, enantiomers, diastereoisomers and mixtures thereof. Also disclosed are the methods of preparation and application in therapeutics of compounds of formula (I).

  这项发明涉及吡唑3,5-羧酸酯的衍生物，其一般式为(I)：其中R1、R2、R3、R4、R5、X、Y、V、W和n如本文所定义。该发明还涉及这些化合物的盐以及其水合物或溶剂合物、对映体、二对映异构体和它们的混合物。还公开了制备方法以及在治疗学中应用式(I)化合物的方法。
• Method for Preparation of Cyano Compounds of the 13th Group with a Lewis Acid
  申请人：LONZA LTD.

  公开号：US20160229874A1

  公开（公告）日：2016-08-11

  The invention discloses a method for preparation of cyano compounds of the 13th group of the periodic table with 1, 2, 3 or 4 cyano residues, represented by formula (I): [Cat n+ ][(Z 1 F 4-m (CN) m ) − ] n by a reaction of [(Z 1 F 4 ) − ] with trimethylsilylcyanide in the presence of a Lewis acid and in the presence of the cation Cat n+ ; Cat n+ is a cation, Z 1 is B, Al, Ga, In or Tl, m is 1, 2, 3 or 4 and n is 1, 2, 3 or 4.

  该发明揭示了一种制备周期表第13族元素的氰基化合物的方法，其具有1、2、3或4个氰基残基，用公式(I)表示：[Catn+][(Z1F4-m(CN)m)−]n，通过[(Z1F4)−]与三甲基硅基氰化物在Lewis酸和阳离子Catn+存在下的反应来实现；其中Catn+是一种阳离子，Z1是B、Al、Ga、In或Tl，m为1、2、3或4，n为1、2、3或4。
• [EN] METHOD FOR PREPARATION OF CYANO COMPOUNDS OF BORON WITH A BRONSTEDT ACID<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS CYANO DE BORE AVEC UN ACIDE DE BRONSTEDT
  申请人：LONZA AG

  公开号：WO2016162400A1

  公开（公告）日：2016-10-13

  The invention discloses a method for preparation of cyano compounds of boron with 1, 2, 3 or 4 cyano residues, represented by formula (I): [Catn+] [(BF4-m(CN)m)- ]n by a reaction of compound of formula (A1) with trimethylsilylcyanide in the presence of a Bronstedt acid; [Catn+] [(BF4)- ]n (A1); n+ Cat is a cation, m is 1, 2, 3 or 4 and n is 1, 2, 3 or 4. In a specific embodiment, the method is for prepration of the following three compounds: [(n-Bu)4N][BF(CN)3] (1), [(n-Pr)3NH][BF(CN)3] (2), [(n-Pr)3NH][B(CN)4] (3).

  该发明揭示了一种制备具有1、2、3或4个氰基的硼氰化合物的方法，其表示为公式（I）：[Catn+] [(BF4-m(CN)m)- ]n，通过化合物公式（A1）与三甲基硅基氰化物在布朗斯特酸存在下的反应实现；[Catn+] [( )- ]n（A1）；n+ Cat为阳离子，m为1、2、3或4，n为1、2、3或4。在特定实施例中，该方法用于制备以下三种化合物：[(n-Bu)4N][BF(CN)3]（1）、[(n-Pr)3NH][BF(CN)3]（2）、[(n-Pr)3NH][B(CN)4]（3）。