dicyclopropyl carbonate | 149674-61-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: dicyclopropyl carbonate
• CAS: 149674-61-3
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: IBVLDEJBDWVBQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dicyclopropyl carbonate 、 6-(2-(4-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1-yl)-2-oxoethyl)-2-(2,6-dioxopiperidin-3-yl)-6,7-dihydropyrrolo[3,4-f]isoindole-1,3(2H,5H)-dione 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 6-(2-(4-(5-(cyclopropanecarbonyl)-3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4.5.6.7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1-yl)-2-oxoethyl)-2-(2,6-dioxopiperidin-3-yl)-6,7-dihydropyrrolo[3,4-f]isoindole-1,3(2H,5H)-dione
  参考文献：
  名称：

  [EN] SMALL MOLECULE DEGRADERS OF CBP/P300 PROTEINS
  [FR] AGENTS DE DÉGRADATION À PETITES MOLÉCULES DE PROTÉINES CBP/P300

  摘要：

  本公开涉及公式(I)的化合物，以及其药学上可接受的盐和溶剂，其中A，m，X，Y，Z和B1的定义如规范所述。本公开还涉及化合物的用途，例如，在治疗或预防对CBP / P300蛋白降解敏感的疾病或疾病中使用（例如癌症）。

  公开号：

  WO2022187417A1
• 作为产物：
  描述：

  环丙醇 、 1,4-pentanediolcarbonate 在 60percent of zinc oxide, 20percent of aluminum oxide, 15percent of stannous oxide, 2.5percent of lanthanum oxide and 2.5percent of cerium oxide; reducing by hydrogen 作用下， 140.0 ℃ 、500.01 kPa 条件下， 反应 2.0h， 以93%的产率得到dicyclopropyl carbonate
  参考文献：
  名称：

  Environment-friendly liquid fuel and production process thereof

  摘要：

  本发明揭示了液体燃料及其生产工艺。该液体燃料包括具有结构式的二烷基碳酸酯，其中R和R'相同或不同，且R和R'选自由C1-C8直链烷基、C3-C8支链烷基、C3-C8萘基和含有呋喃环的烷基组成的群。生产该液体燃料的工艺包括以下步骤：对2-甲基四氢呋喃和二氧化碳进行环加成反应，生成环碳酸酯，然后对环碳酸酯和一元醇进行酯交换反应，生成二烷基碳酸酯。本发明生产的液体燃料洁净、安全、可生物降解；它兼具传统基于化石的液体燃料和生物液体燃料的优点，并具有广泛的应用范围。该工艺为工业生产二烷基碳酸酯提供了一种新途径，实现了生物质资源的高效综合利用。

  公开号：

  EP2664608A1

文献信息

• [EN] SUBSTITUTED METHYLFORMYL REAGENTS AND METHOD OF USING SAME TO MODIFY PHYSICOCHEMICAL AND/OR PHARMACOKINETIC PROPERTIES OF COMPOUNDS<br/>[FR] RÉACTIFS DE MÉTHYLFORMYLE SUBSTITUÉ ET PROCÉDÉ D'UTILISATION DE CEUX-CI POUR MODIFIER DES PROPRIÉTÉS PHYSICOCHIMIQUES ET/OU PHARMACOCINÉTIQUES DE COMPOSÉS
  申请人：SPHAERA PHARMA PRIVATE LTD

  公开号：WO2012137225A1

  公开（公告）日：2012-10-11

  The present invention relates to the synthesis and application of novel chiral/ achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.

  本发明涉及合成和应用新型手性/非手性取代甲基甲酰试剂，用于修改药物和/或生物活性物质，以改变未经修改的原始试剂产生的化合物的物理化学、生物学和/或药代动力学性质。
• ESTROGEN PRODRUGS AND METHODS OF ADMINISTERING ESTROGEN PRODRUGS
  申请人：Evestra, Inc.

  公开号：US20190328658A1

  公开（公告）日：2019-10-31

  Disclosed herein is an intravaginal drug delivery device that includes one or more compartments, each of the one or more compartments comprising an estrogen prodrug and/or a progestin dispersed in a thermoplastic polymeric matrix.

  本文揭示了一种阴道内药物输送装置，其中包括一个或多个隔间，每个隔间包括一种雌激素前药和/或一种孕激素分散在热塑性聚合物基质中。
• ENVIRONMENTAL-FRIENDLY LIQUID FUEL AND PRODUCTION PROCESS THEREOF
  申请人：Beijing Jinjiao Biomass chemical industry Co., Ltd

  公开号：US20130305595A1

  公开（公告）日：2013-11-21

  The present invention discloses a liquid fuel and production process thereof, the liquid fuel comprises dialkyl carbonates with the structural formula of wherein R and R′ are same or different, and R and R′ are selected from the group consisting of C1-C8 linear chain alkyl, C3-C8 branched chain alkyl, C3-C8 naphthene base and alkyl containing furan ring. The process of the production of the liquid fuel comprises the steps of: performing a cycloaddition reaction between 2-methyl tetrahydrofuran produced by hydrogenation from furfural which is a biomass derivative and carbon dioxide to produce a cyclic carbonate (i.e. 1,4-pentanediol carbonate), then performing an ester exchange reaction between the cyclic carbonate and monohydric alcohol to produce the dialkyl carbonate. The liquid fuel produced by the present invention is clean, safe and biodegradable; it is compatible with advantages of conventional fossil-based liquid fuels and biological liquid fuels and with a wide range of applications, the process provides a new way for industrial production of the dialkyl carbonate and efficient and comprehensive utilization of biomass resources, the economic and social benefit is remarkable. The present invention discloses a liquid fuel and production process thereof, the liquid fuel comprises dialkyl carbonates with the structural formula of wherein R and R′ are same or different, and R and R′ are selected from the group consisting of C1-C8 linear chain alkyl, C3-C8 branched chain alkyl, C3-C8 naphthene base and alkyl containing furan ring. The process of the production of the liquid fuel comprises the steps of: performing a cycloaddition reaction between 2-methyl tetrahydrofuran produced by hydrogenation from furfural which is a biomass derivative and carbon dioxide to produce a cyclic carbonate (i.e. 1,4-pentanediol carbonate), then performing an ester exchange reaction between the cyclic carbonate and monohydric alcohol to produce the dialkyl carbonate. The liquid fuel produced is clean, safe and biodegradable, and the process provides a new way for industrial production of the dialkyl carbonate with remarkable economic and social benefit.

  本发明披露了一种液体燃料及其生产工艺，该液体燃料包括具有结构式的二烷基碳酸酯其中R和R'相同或不同，R和R'被选自由C1-C8线性链烷基，C3-C8支链烷基，C3-C8萘基和含有呋喃环的烷基组成的群体。该液体燃料的生产过程包括以下步骤：通过将生物质衍生物糠醛氢化产生的2-甲基四氢呋喃和二氧化碳进行环加成反应以产生环状碳酸酯（即1,4-戊二醇碳酸酯），然后通过将环状碳酸酯和单元醇进行酯交换反应以产生二烷基碳酸酯。本发明生产的液体燃料洁净、安全、可生物降解，具有常规化石燃料和生物燃料的优点，适用范围广泛，该工艺为工业生产二烷基碳酸酯和高效综合利用生物质资源提供了新的途径，具有显著的经济和社会效益。
• Catalysts used for producing carbonic acid esters and methods of producing carbonic acid esters using the same
  申请人：JGC Corporation

  公开号：EP0528498A2

  公开（公告）日：1993-02-24

  The present invention relates to a novel catalyst having a stable catalytic activity for catalyzing the reaction of an alcohol with carbon monoxide and oxygen to produce carbonic acid esters (i.e., carbonate), and also the present invention relates to a method of producing carbonic acid esters using this catalyst. The catalyst of the present invention comprises a copper halide and at least one hydroxide compound selected from a group consisting of alkali metal hydroxides and alkali earth metal hydroxides carried on a porous carrier, and also provide a process of regenerating a catalytic activity of the catalyst.

  本发明涉及一种新型催化剂，该催化剂具有稳定的催化活性，可催化醇与一氧化碳和氧反应生成碳酸酯（即碳酸盐），本发明还涉及一种使用该催化剂生产碳酸酯的方法。本发明的催化剂由卤化铜和至少一种氢氧化物组成，这些氢氧化物选自多孔载体上的碱金属氢氧化物和碱土金属氢氧化物，本发明还提供了一种再生催化剂催化活性的方法。
• Process for the preparation of poly (arylcarbonate)s
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0890596A1

  公开（公告）日：1999-01-13

  A process for the preparation of poly(arylcarbonate)s, comprising reaction of dialkyl carbonates with bisphenols in the presence of selected distannoxane compounds in a first step to obtain an oligo(arylcarbonate). The oligomer is then polycondensed in a second step, either by itself or with diphenyl carbonate, using an organo-tin or -titanium catalyst. The process yields aromatic polycarbonates that are characteristically free of color and gel.

  一种制备聚(芳基碳酸酯)的工艺，包括碳酸二烷基酯与双酚在选定的二annoxane 化合物存在下进行第一步反应，得到低聚(芳基碳酸酯)。然后在第二步中，使用有机锡或钛催化剂，将低聚物本身或与碳酸二苯酯进行缩聚。该工艺生产出的芳香族聚碳酸酯通常不含色素和凝胶。