4-(4-Methylpiperazin-4-ium-1-yl)-3-nitrobenzoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-Methylpiperazin-4-ium-1-yl)-3-nitrobenzoate
• 化学式: C12H15N3O4
• mdl: MFCD01568172
• 分子量: 265.26
• InChiKey: OELXEJIGVMEIJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  89.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A<br/>[FR] DÉRIVÉS DE CYCLOPROPYLAMINE UTILES EN TANT QU'INHIBITEURS DE HISTONE DÉMÉTHYLASES KDM1A
  申请人：ISTITUTO EUROP DI ONCOLOGIA S R L

  公开号：WO2014086790A1

  公开（公告）日：2014-06-12

  (I) The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.

  本发明涉及一般式(I)的环丙基衍生物，其中A、R1和R2如规范中定义。本申请还涉及含有这类化合物的药物组合物以及它们在治疗中的应用。
• Macrolide antibiotics
  申请人：Alihodzic Sulejman

  公开号：US20050215495A1

  公开（公告）日：2005-09-29

  The present invention relates to 11,12 γ lactone ketolides of formula (I) wherein R, R 1 , R 2 , R 3 are as defined herein and pharmaceutically acceptable salts and solvates thereof, to process for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.

  本发明涉及式（I）的11,12γ内酯酮类药物，其中R，R1，R2，R3如本文所定义，并且其药学上可接受的盐和溶剂合物，以及其制备过程和在人体或动物体内治疗或预防系统性或局部细菌感染中的用途。
• CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A
  申请人：INSTITUTO EUROPEO DI ONCOLOGIA S.R.L.

  公开号：US20150315126A1

  公开（公告）日：2015-11-05

  The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R 1 , and R 2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.

  本发明涉及一般式(I)的环丙基衍生物，其中A、R1和R2如规范中所定义。本申请还涉及含有这种化合物的药物组合物以及它们在治疗中的使用。
• BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS
  申请人：Bandiera Tiziano

  公开号：US20090136513A1

  公开（公告）日：2009-05-28

  A compound having formula (I): wherein: R, A, R 1 and R 2 , are as defined in the specification, and pharmaceutical formulas thereof, and methods of use thereof, as Kinase inhibitors.

  化合物的化学式为（I）：其中：R，A，R1和R2如规范中所定义，以及其药物配方和作为激酶抑制剂的使用方法。
• MACROLIDE ANTIBIOTICS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1363925B1

  公开（公告）日：2006-11-15