(4aS,11aS)-N-[(3-chloro-2-fluoro-phenyl)methyl]-6-hydroxy-4a-methyl-5,7-dioxo-3,4,11,11a-tetrahydro-2H-pyrano[3,2-b]quinolizine-8-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: (4aS,11aS)-N-[(3-chloro-2-fluoro-phenyl)methyl]-6-hydroxy-4a-methyl-5,7-dioxo-3,4,11,11a-tetrahydro-2H-pyrano[3,2-b]quinolizine-8-carboxamide
• 英文别名: (4aS,11aS)-N-[(3-chloro-2-fluorophenyl)methyl]-6-hydroxy-4a-methyl-5,7-dioxo-3,4,11,11a-tetrahydro-2H-pyrano[3,2-b]quinolizine-8-carboxamide
• 化学式: C₂₁H₂₀ClFN₂O₅
• 分子量: 434.8
• InChiKey: VOAMQBJTMBGTOF-SZNDQCEHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Substituted quinolizine derivatives useful as HIV integrase inhibitors
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US10201533B2

  公开（公告）日：2019-02-12

  The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.

  本发明涉及式（I）的取代喹嗪衍生物： 及其药学上可接受的盐或原药，其中 X、Y、R1、R2、R3、R4、R5、R9 和 R10 如本文所定义。本发明还涉及包含至少一种被取代的喹嗪衍生物的组合物，以及使用被取代的喹嗪衍生物治疗或预防受试者HIV感染的方法。
• SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20160228419A1

  公开（公告）日：2016-08-11

  The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 9 and R 10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
• US9861620B2
  申请人：——

  公开号：US9861620B2

  公开（公告）日：2018-01-09