(S)-N-(2-methoxy-3-dibenzofuranyl)-2-pyrrolidinecarboxamide | 1096141-19-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (S)-N-(2-methoxy-3-dibenzofuranyl)-2-pyrrolidinecarboxamide
• 英文别名: (2S)-N-(2-methoxydibenzofuran-3-yl)pyrrolidine-2-carboxamide
• CAS: 1096141-19-3
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: DHXPDDNEWFPYQB-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  63.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 、 (S)-N-(2-methoxy-3-dibenzofuranyl)-2-pyrrolidinecarboxamide 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 0.5h， 生成 (S)-chloro[(1,2,3,4-η)-pentamethyl-2,4-cyclopentadien-1-yl] [N-(2-methoxy-3-dibenzofuranyl)-2-pyrrolidinecarboxamidato-κN1,κN2]iridium
  参考文献：
  名称：

  METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE

  摘要：

  公开号：

  EP2172443B1
• 作为产物：
  描述：

  3-氨基-2-甲氧基二苯并呋喃 、 (S)-N-(2-methoxy-3-dibenzofuranyl)-2-pyrrolidinecarboxamide hydrochloride 在 sodium hydroxide 作用下， 以 水 、 四氢呋喃 为溶剂， 生成 (S)-N-(2-methoxy-3-dibenzofuranyl)-2-pyrrolidinecarboxamide
  参考文献：
  名称：

  METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE

  摘要：

  公开号：

  EP2172443B1

文献信息

• Method for Producing Optically Active Alcohols
  申请人：HAMARI CHEMICALS, LTD.

  公开号：US20140296584A1

  公开（公告）日：2014-10-02

  A method is provided for producing optically active alcohols from ketones by reducing a ketone in the presence of an iridium(III) complex having a chiral prolinamide compound as a ligand. The ketone is preferably a compound represented by formula [I]: (wherein R 1 and R 2 are different from each other, and each represent an optionally substituted straight or branched alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group, an optionally substituted heteroarylalkyl group, an optionally substituted alkenyl group or an optionally substituted alkynyl group, and R 1 and R 2 may be bound to each other at any appropriate position to form a ring, the ring optionally containing one or more atoms which may be the same or different and are selected from an oxygen atom, an optionally substituted nitrogen atom and a sulfur atom, and optionally being condensed with an aromatic or hetero-aromatic ring).

  本发明提供了一种通过在具有手性脯氨酰胺化合物作为配体的铱(III)络合物存在下还原酮来制备光学活性醇的方法。所述酮优选为由公式[I]表示的化合物：（其中R1和R2不同，每个表示可选取代的直链或支链烷基、可选取代的环烷基、可选取代的芳基、可选取代的杂芳基、可选取代的芳基烷基、可选取代的杂芳基烷基、可选取代的烯基或可选取代的炔基，R1和R2可以在任何适当的位置结合形成环，所述环可选包含一个或多个原子，所述原子可以相同或不同，所述原子选自氧原子、可选取代的氮原子和硫原子，并且可选与芳香或杂芳香环融合）。
• METHOD FOR PRODUCING OPTICALLY ACTIVE TETRAHYDROQUINOLINES
  申请人：Maeda Sadayuki

  公开号：US20140228572A1

  公开（公告）日：2014-08-14

  Provided are a novel chiral iridium(III) complex; and a method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines from 2-substituted-quinolines with the use of the chiral iridium(III) complex through a more economical and easy production process. The disclosed method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines comprises reducing a quinoline compound represented by formula [I]: in the presence of a hydrogen donor compound and an iridium (III) complex having a chiral prolinamide compound as a ligand to give an optically active 2-substituted-1,2,3,4-tetrahydroquinoline represented by formula [II]:

  提供了一种新颖的手性铱(III)配合物；以及一种使用该手性铱(III)配合物通过更经济、更简便的生产工艺从2-取代喹啉制备手性活性的2-取代-1,2,3,4-四氢喹啉的方法。所披露的制备手性活性的2-取代-1,2,3,4-四氢喹啉的方法包括在氢供体化合物和含有手性脯氨酰胺化合物配体的铱(III)配合物的存在下还原由式[I]表示的喹啉化合物，以得到由式[II]表示的手性活性的2-取代-1,2,3,4-四氢喹啉。
• METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL
  申请人：Hamari Chemicals, Ltd.

  公开号：EP2772476B1

  公开（公告）日：2017-01-11
• METHOD FOR PRODUCING OPTICALLY ACTIVE TETRAHYDROQUINOLINE
  申请人：Hamari Chemicals, Ltd.

  公开号：EP2733138B1

  公开（公告）日：2016-09-28
• METHOD FOR PRODUCING OPTICALLY ACTIVE AMINES
  申请人：Maeda Sadayuki

  公开号：US20100160636A1

  公开（公告）日：2010-06-24

  The present invention provides a method for producing chiral amines, comprising asymmetric transfer hydrogenation of imine compounds in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand. The present invention is useful for production of chiral amines in an efficient manner in terms of their optical and chemical yields.