N-(6-aminohexyl)-6-[1,1-dimethyl-2-[5-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)penta-2,4-dienylidene]benzo[e]indol-3-yl]hexanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(6-aminohexyl)-6-[1,1-dimethyl-2-[5-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)penta-2,4-dienylidene]benzo[e]indol-3-yl]hexanamide
• 化学式: C46H57N4O+
• 分子量: 682.0
• InChiKey: FOAHMUGMCCWIPV-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  51
• 可旋转键数：
  15
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NANOPARTICLE ENCAPSULATION TO TARGET G PROTEIN-COUPLED RECEPTORS IN ENDOSOMES
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20220031849A1

  公开（公告）日：2022-02-03

  The present invention relates to methods for modulating endosomal GPCR signaling. In particular, the present invention relates to use of polymeric nanoparticles for the targeted delivery of hydrophobic modulators of endosomal GPCRs and their use in the treatment of associated diseases and disorder.